TIF1-Gamma for Treating and Diagnosing Inflammatory Diseases

A method of preventing or treating an inflammatory disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a TIF1γ-encoding polynucleotide or a TIF1γ polypeptide.

A method for screening a compound capable of promoting and/or restoring the resolution of inflammation, comprising the step of identifying a compound that activates the expression of TIF1γ or identifying a compound that mimics TIF1γ transcriptional activity.

A transgenic non-human animal which is TIF1γ-deficient in myeloid cells.

A method for diagnosing or predicting an inflammatory disease, or a risk of an inflammatory disease, in a subject, said method comprising detecting a mutation in the TIF1γ gene in a sample obtained from said subject, wherein the presence of a TIF1γ mutation is indicative of an inflammatory disease or of a risk of an inflammatory disease.

A method for diagnosing or predicting an inflammatory disease, or a risk of an inflammatory disease, in a subject, said method comprising (i) detecting the level of expression of the TIF1γ gene in a sample obtained from said subject, and (ii) comparing said level of expression with a predetermined reference value, wherein a decrease in the level of expression of the TIF1γ gene is indicative of an inflammatory disease or of a risk of an inflammatory disease.

(canceled)