Endospore compositions and uses thereof

A composition comprising:

• (a) one or more germinants;
• (b) polyolprepolymer-2 or poly(styrene-co-maleic anhydride) copolymers (SMA);
• (c) one or more nanoscale particle having a particle size of about 5 nm to about 200 nm;
• and (d) a carrier.

A composition comprising:

• (a) one or more germinants;
• (b) polyolprepolymer-2 or poly(styrene-co-maleic anhydride) copolymers (SMA);
• and (d) a carrier;
• wherein the germinant is:
• (a) a compound of Formula I:
• wherein
• R1 is H, alkyl, cycloalkyl, OH, alkoxy, or halo;
• R2 is H, alkyl, cycloalkyl, OH, or alkoxy;
• R3 and R4 are independently alkyl or H;
• R5 is alkyl or cycloalkyl;
• X is O, CH2, or S;
• Y is CH or N;
• and
• Z is C or B;
• or salts thereof;
• or
• (b) a compound of Formula II:
• wherein
• R1 is H, alkyl, OH, alkoxy, or halo;
• R2 is OH, alkyl, alkoxy, halo, amino, aminoalkyl, aminodialkyl, alkylamino, alkylaminoalkyl, CO2R6, COR6, or CON(R6)2;
• wherein each R6 is independently H or alkyl;
• or
• has the structure of Formula IIa:
• wherein
• each R3 is independently H, alkyl, alkoxy, CO2R6, or halo;
• R4 is H, alkyl, OH, alkoxy, or halo;
• R5 is H, alkyl, OH, alkoxy, halo, SO3H, PO3H, CO2R6, COR6, CONR6, aminoalkyl, amino, N(R6)benzyl, or N(R6)phenyl;
• each R6 is independently H or alkyl;
• and
• n is 0, 1, 2, 3, 4, or 5;
• or
• has the structure of Formula IIb:
• wherein
• R3 is H, alkyl, alkoxy, CO2R6, or halo;
• R4 is H, alkyl, OH, alkoxy, or halo;
• X is NR6, O or C(R6)2;
• Y is SO3H, PO3H, CO2R6, CONR6, H, alkyl, OH, alkoxy, halo, aminoalkyl, or amino;
• and
• each R6 is independently H or alkyl;
• n is 0, 1, 2, 3, 4, or 5;
• or
• a salt thereof;
• or
• 2,3,3,4(2H)-Furantetrol, dihydro-2-methyl-, (2R,4S)-
• 2,3,3,4(2/-I)-Furantetrol, dihydro-2-methyl-, (2S,4S)-
• 2,3,3,4(2H)-Furantetrol, dihydro-2-methyl-, (45)-
• 2,3,3,4(2H)-Furantetrol, dihydro-2-(methyl-13C)-, (2S,4S)- (9CI)
• 2,3,3,4(2H)-Furantetrol, dihydro-2-(methyl-13C)-, (2R,4S)- (9CI)
• 2,3,3,4(2H)-Furantetrol, dihydro-2-(methyl-13C)-, (4S)-
• 2,3,3,4(2H)-Furantetrol-2-13C, dihydro-2-(methyl-13C)-, (4S)-
• 2,3,3(2H)-Furantriol, dihydro-4-methoxy-2-methyl-
• 2,3,3(2H)-Furantriol, 4-ethoxydihydro-2-methyl
• 2,3,3(2H)-Furantriol, dihydro-2-methyl-4-propoxy-
• 3-Furanol, tetrahydro-2,4,4,5-tetramethoxy-5-methyl-
• 2,3,3,4(2H)-Furantetrol, dihydro-2-(trifluoromethyl)-,(4S)-
• 2,3,3(2H)-Furantriol, 4-(hexyloxy)dihydro-2-methyl-
• 2,3,3(2H)-Furantriol, dihydro-2-methyl-4-(phenylmethoxy)-
• Borate(1-),[[(2S,3S,4S)-dihydro-2-methyl-2,3,3,4(2H)-furantetrolato(2-)-KO3,KO4]dihydroxy-, (T-4)-
• 3,4-Furandiol, tetrahydro-2,5-dimethoxy-2-methyl- (7CI)
• erythro-2-Hexulofuranose, 1,6-dideoxy-5-C-niethoxy-(5E1)-(9CI)
• 2-Hexulofuranoside, methyl 1,6-dideoxy-5-C-methoxy-, (9CI)
• α-D-Psicofuranose, 5-C-hydroxy- (9CI)
• β-D-Psicofuranose, 5-C-hydroxy- (9CI)
• β-L-Tagatofuranose, 5-C-hydroxy- (9CI)
• 3,4-Furandiol, tetrahydro-2-(hydroxymethyl)-2,5-dimethoxy- (9CI)
• 3-Furanol, tetrahydro-2,4,4,5-tetramethoxy-5-methyl-
• 2-Furoic acid, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-(6CI)
• 2-Furaldehyde, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-, dimethyl acetal (6CI)
• 3,4-Furandiol, tetrahydro-2,5-dimethoxy-2-methyl-, diacetate (7CI)
• 2-Furoic acid, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-, methyl ester (6C1,7CI)
• D-erythro-Pentofuranose, 5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-, (4ξ)-(9CI)
• β-D-Fructofuranose, 5-C-hydroxy-, 1-(dihydrogen phosphate) (9CI)
• 2-Furoic acid, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-5-methyl-, methyl ester (7CI)
• 2-Furamide, tetrahydro-3,4-dihydroxy-2,5-dimethoxy- (6CI)
• Furfuryl alcohol, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-, acetate (6CI)
• α-D-Glucopyranoside, 4-C-hydroxy-α-D-arabinofuranosyl (9CI)
• Pentofuranoside, methyl 5-deoxy-3-C-(dimethoxymethyl)-4-C-methoxy- (9CI)
• D-erythro-Pentofuranoside, methyl 5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-, (4ξ)- (9CI)
• D-erythro-Pentofuranoside, methyl 5-deoxy-4-C-methoxy-2,3-O-(1-methylethylidene)-, (4ξ)- (9CI)
• α-D-Fructofuranose, 5-C-hydroxy-, 1,6-bis(dihydrogen phosphate) (9CI)
• β-D-Fructofuranose, 5-C-hydroxy-, 1,6-bis(dihydrogen phosphate) (9CI)
• α-D-ribo-Hexopyranosid-3-ulose, (4R)-4-C-hydroxy-β-D-arabinofuranosyl (9CI)
• α-D-Galactopyranoside, (5S)-5-C-hydroxy-β-D-threo-2-pentulofuranosyl (9CI)
• α-D-Glucopyranoside, (5S)-5-C-hydroxy-β-D-threo-2-pentulofuranosyl (9CI)
• 2,7,12,13-Tetraoxatricyclo[7.2.1.13,6]tridecane-4,5,9,10,11-pentol, 3-(hydroxymethyl)-1,6-dimethyl-, (4S,5R,10S,11R)-
• β-D-Xylofuranose, 1,5-anhydro-4-C-(α-D-glucopyranosyloxy)- (9CI)
• 2-Furoic acid, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-, -methyl ester, diacetate (7CI)
• β-D-threo-2,5-Hexodiulo-2,6-pyranose, 5-hydrate, 5,21:5,31-dianhydride with 5-C-hydroxy-α-L-sorbofuranose (9CI)
• D-erythro-Pentofuranose, 5-bromo-5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-, (4ξ)-
• D-erythro-Pentofuranose, 5-deoxy-4-C-hydroxy-5-iodo-2,3-O-(1-methylethylidene)-, (4ξ)-
• 3,4-Furandiol, 2-[(benzoyloxy)methyl]tetrahydro-2,5-dimethoxy-(9CI)
• β-D-ribo-Pentofuranoside, methyl 5-bromo-5-deoxy-4-C-hydroxy-2,3,O-(1-methylethylidene)-
• α-L-lyxo-Pentofuranoside, methyl 5-bromo-5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-
• α-D-ribo-Pentofuranoside, methyl 5-bromo-5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-
• β-L-lyxo-Pentofuranoside, methyl 5-bromo-5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-
• D-erythro-Pentofuranoside, methyl 5-bromo-5-deoxy-4-C-hydroxy-2,3-O-(1-methylethylidene)-, (4ξ)-
• D-erythro-Pentofuranoside, methyl 5-deoxy-4-C-hydroxy-5-iodo-2,3-O-(1-methylethylidene)-, (4ξ)-
• Pentofuranoside, methyl 5-deoxy-3-C-(dimethoxymethyl)-4-C-methoxy-2,3-bis-O-(trimethylsilyl)- (9CI)
• Furo[3,4-d]-1,3,2-dioxaphosphol-4-ol, tetrahydro-2,6-dimethoxy-4,6-dimethyl-, 2-oxide (9CI)
• D-erythro-L-ribo-5-Nonuto-5,2-furanose, 5,9-anhydro-1,6,7,8-tetradeoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]2-C-hydroxy-6,8-dimethyl-4-O-methyl-, (5S)- (9CI)
• Pentofuranoside, methyl 5-deoxy-3-C-(dimethoxymethyl)-4-C-methoxy-, diacetate (9CI)
• 13,14-Dioxatricyclo[8.2.1.14,7]tetradecane-5,6,11,12-tetrol, 1,4,7,10-tetramethoxy-
• 3,4-Furandiol, tetrahydro-2,5-dimethoxy-2-methyl-, dibenzoate (7CI)
• β-D-Ribofuranoside, (2-nitrophenyl)methyl 4-C-methoxy-
• β-L-erythro-Hexofuranosid-5-ulose, methyl 6-deoxy-4-C-methoxy-2,3-O-(1-methylethylidene)-, (S)- (9CI)
• α-D-Lyxofuranose, 4-C-ethoxy-5-O-(phenylmethyl)-, triacetate (9CI)
• β-D-Lyxofuranose, 4-C-ethoxy-5-O-(phenylmethyl)-, triacetate (9CI)
• β-D-Ribofuranoside, (2-nitrophenyl)methyl 4-C-methoxy-2-O-methyl-
• α-D-Glucofuranose, 4-O-methyl-1,2:5,6-bis-O-(1-methylethylidene)-2,3,7-Trioxabicyclo[2.2.1]heptane-5,6-diol, 1,4-dimethyl-, dinitrate, (5-endo, 6-exo)- (9CI)
• Galactitol, 2,5-anhydro-1,6-dideoxy-2,5-dimethoxy-3,4-di-C-methyl-, cyclic 3,4-(hydrogen phosphate) (8CI)
• a-D-Tagatofuranoside, methyl 1,6-dideoxy-5-C-methoxy-3,4-di-C-methyl-, cyclic hydrogen phosphate (9CI)
• β-D-Riboruranoside, methyl 4-C-(1-cyanoethoxy)-5-deoxy-2,3-O-(1-methylethylidene)- (9CI)
• Phosphoric acid, methyl ester, cyclic 3,4-ester with tetrahydro-5-methoxy-2,3,4,5-tetramethyl-2,3,4-furantriol (7CI)
• α-L-Tagatofuranose, 2,5-anhydro-1,6-dideoxy-5-C-methoxy-3,4-di-C-methyl-, cyclic 3,4-(methyl phosphate), (R)-(9CI)
• α-L-Tagatofuranose, 1,6-dideoxy-5-C-methoxy-3,4-di-C-methyl-, cyclic 3,4-(methyl phosphate), (S)- (9CI)
• Fructofuranose, O-α-D-galactopyranosyl-(1→6)-O-α-D-glucopyranosyl-6-t-(1→4)-, β-D- (8CI)
• Raffinose-6′-t (8CI)
• SaH-Oxireno[8,8a]naphtho[2,3-b]furan-5a,6-diol, decahydro-7,8a-dimethoxy-4,4a,6-trimethyl-, (1aR,4S,4aR,5aR,6S,7S,8aS,9aS)-
• Molybdate(1-), [μ-[1,6-dideoxy-5-C-hydroxy-3,4-di-C-methyl-α-psicofuranosato(3-)-O2,O3:O3,O4]]-μ-oxotetraoxodi-, steroisomer (9CI)
• 1-Butanaminium, N,N,N-tributyl-, stereoisomer of [μ-[1,6-dideoxy-5-C-hydroxy-3,4-di-C-methyl-α-psicofuranosato(3-)-O2,O3:O3,O4]]-oxo-tetraoxodimolybdate(1-) (9CI)
• 1-Butanaminium, N,N,N-tributyl-, stereoisomer of [μ-[1,6-dideoxy-5-C-hydroxy-3,4-di-C-methyl-α-psicofuranosato(3-)-O2,O3:O3,O4]]-μ-oxo-tetraoxodimolybdate(1-), compd. with 1,1′-oxybis[ethane](2:1) (9CI)
• 9a H-4a,8-Epoxy-1,3-dioxolo[4,5]furo[2,3-d]oxepin-9a-ol, hexahydro-2,2,8-trimethyl-, [3aS-(3aα,4aα,8α,9aβ,9bα)]-(9CI)
• α-Lyxofuranoside, methyl 3-C-[(benzoyloxy)methyl]-5-deoxy-4-C-methoxy-, 2-acetate (9CI)
• 2-Furoic acid, tetrahydro-3,4-dihydroxy-2,5-dimethoxy-, methyl ester, dibenzoate (7CI)
• β-D-ribo-Heptofuranoside, methyl 4,6-anhydro-5,7-dideoxy-4-C-hydroxy-6-Cmethyl-2,3-O-(1-methylethylidene)- (9CI)
• β-L-Sorbofuranose, 5-C-hydroxy-1,3:4,6-bis-O-(phenylmethylene)-, [1(R),4(R)]- (9CI)
• β-L-Sorbofuranose, 5-C-hydroxy-1,3:4,6-bis-O-(phenylmethylene)-(9CI)
• α-D-Glucofuranose, 4-O-methyl-1,2:5,6-bis-O-(1-methylethylidene)-, 3-acetate
• α-D-Galactofuranose, 4-O-methyl-1,2:5,6-bis-O-(1-methylethylidene)-, 3-acetate
• 2,4,6-Metheno-2H-cyclopenta[g]furo[2,3,4-ij][2]benzopyran-2,5a,6a,9a,9b,9c(2aH,6H,7H)-hexol, tetrahydro-2a,6,9-trimethyl-4-(1-methylethyl)-, (2S,2aS,4S,5aR,6S,6aS,9R,9aS,9bR,9cS,10S)- (9CI)
• Furo[2,3-d:4,5-d]bis[1,3]dioxole, tetrahydro-2,2,3a,6,6,7b-hexamethyl-, (3aα,4aα,7aβ,7bβ)- (9CI)
• 1,4a-(Epoxymethano)-4aH-xanthen-9 (2H)-one, 1,3,4,9a-tetrahydro-1,9a-dihydroxy-11-methoxy-
• α-L-Sorbofuranose, 5-C-methoxy-1,3:4,6-bis-O-(phenylmethylene)-, [1(R),4(R),5S]- (9CI)
• Furo[2,3-d:4,5-d]bis[1,3]dioxole, tetrahydro-2,2,3a,4a,6,6-hexamethyl-, (3aα,4aβ,7aβ,7bα)- (9CI)
• Spiro[furan-2(3H),4′(3′aH)-furo[3,4-d][1,3]dioxole], 6′,6′a-dihydro-6′-methoxy-2′,2′-dimethyl-, (2R,3′aS,6′R,6′aR)-
• Octofuranosiduronic acid, methyl 3,6-anhydro-5-deoxy-4-C-methoxy-6-C-(methoxycarbonyl)-, methyl ester (9CI)
• β-L-erythro-Hexofuranosid-5-ulose, methyl 6-deoxy-4-C-methoxy-2,3-O-(1-methylethylidene)-, oxime, (4R)- (9CI)
• 2-Propanone, 1-hydroxy-1-[tetrahydro-6-hydroxy-2,3a,5-trimethyl-5,2-(epoxymethano)furo[2,3-d]-1,3-dioxol-8-yl]-, [2R-[2α,3aβ,5α,6β,6aβ,8S*(R*)]]- (9CI)
• β-L-erythro-β-L-lyxo-Decofuranos-7-ulo-7,10-furanose, 10-C-(acetyloxy)-3,7-anhydro-5,6-dideoxy-, tetraacetate, (10R)- (9CI)
• Inulobiose, octaacetate (5CI)
• 2,3,7-Trioxabicyclo[2.2.1]heptane-1-acetonitrile, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-4-methyl-, (1R,4S,5R,6R)-
• D-gluco-Nonitol, 2,5-anhydro-1,6,7,8-tetradeoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-2,5-C-epidioxy-6,8-dimethyl-4-O-methyl-, (2ξ,5ξ)- (9CI)
• β-D-Lyxofuranose, 4-C-ethoxy-2,3-O-(1-methylethylidene)-5-O-(phenylmethyl)-, acetate (9CI)
• 2-Heptenal, 6-[(5S,6R)-5-hydroxy-6-methoxy-4-methyl-2,3,7-trioxabicyclo[2.2.1]hept-1-yl]-4-methyl-, (2E,4S,6R)-
• Spiro[1,2-dioxin-3(6H),5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-2′,2′,6-trimethyl-, 6′-acetate, (3R,3′aS,6′R,6′aR)-
• Spiro[1,2-dioxin-3(6H), 5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-2′,2′,6-trimethyl-, 6′-acetate, (3S,3′aS,6′R,6′aR)-
• 5,8-Epoxy-1,4-dioxino[2,3-d][1,2]dioxin, hexahydro-4a,5,8,8a-tetramethyl-, (4aR,5S,8R,8aS)-rel-
• 5,8-Epoxy-1,4-dioxino[2,3-d][1,2]dioxin, hexahydro-4a,5,8,8a-tetramethyl-, (4aR,5R,8S,8aS)-rel-
• 5,8-Epoxy-1,4-dioxino[2,3-d][1,2]dioxin, hexahydro-4a,5,8,8a-tetramethyl-
• 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-[(4-C-hydroxy-α-D-ribofuranosyl)oxy]- (9CI)
• Furo[2,3-d:4,5-d]bis[1,3]dioxole, tetrahydro-2,2,3a,4a,6,6,7a,7b-octamethyl-, (3aα,4aα,17aβ,7bβ)- (9CI)
• 6,9-Epoxy-2H-o-dioxino[4,5-b][1,4]dioxepin, hexahydro-5a,6,9,9a-tetramethyl-, stereoisomer (8CI)
• 6,9-Epoxy-2H-o-dioxino[4,5-b][1,4]dioxepin, hexahydro-5a,6,9,9a-tetramethyl-, stereoisomer (8CI)
• L-gulo-Nonose, 5,8-anhydro-2,3,4,9-tetradeoxy-7-O-[(1,1-dimethylethyl)dimethylsilyl]-5,8-C-epidioxy-2,4-dimethyl-6-O-methyl-, (5ξ,8ξ)- (9CI)
• α-L-Sorbofuranose, 5-C-methoxy-1,3:4,6-bis-O-(phenylmethylene)-, acetate, [1(R),4(R),5S]- (9CI)
• Spiro[1,2-dioxin-3(6H),5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6-ol, 6′,6′a-dihydro-6′-methoxy-6-methyl-2′-(trichloromethyl)-, (2′S,3S,3′aS,6′R,6′aR)-
• Spiro[1,2-dioxin-3(6H),5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6-ol, 6′,6′a-dihydro-6′-methoxy-6-methyl-2′-(trichloromethyl)-, (2′R,3R,3′aS,6′R,6′aR)-
• 7,10-Epoxy[1,2]dioxino[4,5-b][1,4]dioxocin, octahydro-6a,7,10,10a-tetramethyl-
• Furo[2,3-d:4,5-d]bis[1,3]dioxole-3a(4aH)-carboxylic acid, dihydro-2,2,6,6-tetramethyl- (9CI)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6′-ol, octahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,3bR,5S,6′S,6′aR,7aS,8aR)-
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, octahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,3bR,5S,6′S,6′aR,7aR,8aR)- (9CI)
• Spiro[1,2-dioxin-3(6H),5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-2′,2′,6-trimethyl-, 6,6′-diacetate, (3S,3′aS,6′R,6′aR)-
• Spiro[1,2-dioxin-3(6H),5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-2′,2′,6-trimethyl-, 6,6′-diacetate, (3R,3′aS,6′R,6′aR)-
• 2H-Naphtho[1,2-b]pyran-2-one, 6-[[5-C-(α-D-glucopyranosyloxy)-β-D-fructofuranosyl]oxy]-7-hydroxy-3-methyl-
• Spiro[furo[3,4-d]-1,3-dioxole-4(3aH),5′(4′H)-isoxazole], 6,6a-dihydro-6-methoxy-2,2,3′-trimethyl-, (3aS,4R,6R,6aR)-
• Spiro[1,2-dioxin-3 (6H),5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-6-methyl-2′-(trichloromethyl)-, 6′-acetate, (2′S,3S,3′aS,6′R,6′aR)-
• Spiro[1,2-dioxin-3(6H), 5′(3′aH)-furo[2,3-d][1,3]dioxole]-6,6′-diol, 6′,6′a-dihydro-6-methyl-2′-(trichloromethyl)-, 6′-acetate, (2′R,3R,3′aS,6′R,6′aR)-
• ε-D-Glucofuranose, 4-C-hydroxy-1,2:5,6-bis-O-(1-methylethylidene)-, 3-(3-chlorobenzoate)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, 3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,5S,6′S,6′aR,8aR)-
• Spiro[furo[3,4-d]-1,3-dioxole-4(3aH),5′(4′H)-isoxazole], 3′-ethyl-6,6a-dihydro-6-methoxy-2,2-dimethyl-, (3aS,4R,6R,6aR)-
• 1,4-Epoxy-o-dioxino[4,5-b][1,4]benzodioxin, 1,4,4a,10a-tetrahydro-1,4,4a,10a-tetramethyl-, stereoisomer (8CI)
• 1,4-Epoxy-o-dioxino[4,5-b][1,4]benzodioxin, 1,4,4a,10a-tetrahydro-1,4,4a,10a-tetramethyl-, stereoisomer (8CI)
• 1,4:6,9-Diepoxy-p-dioxino[2,3-d:5,6-d]bis-o-dioxin, octahydro-1,4,4a,5a,6,9,9a,10a-octamethyl-, stereoisomer (8CI)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, 6′-(aminomethyl)octahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,3bR,5S,6′S,6′aR,7aS,8aR)- (9CI)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, 6′-(aminomethyl)octahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, octahydro-2,2,2′,2′-tetramethyl-, 6′-acetate, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, 6′-(1-aminoethyl)-3a,3b,6,6′,6′a,7,7a,8a-octahydro-2,2,2′,2′-tetramethyl-, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-
• L-glycero-β-D-gulo-Octofuranuronic acid, 4-C-(acetyloxy)-3,6-anhydro-5-deoxy-6-C-(methoxycarbonyl)-, methyl ester, 1-acetate 2,7-dibenzoate (9CI)
• L-glycero-α-D-gulo-Octofuranuronic acid, 4-C-(acetyloxy)-3,6-anhydro-5-deoxy-6-C-(methoxycarbonyl)-, methyl ester, 1-acetate 2,7-dibenzoate (9CI)
• L-glycero-β-D-allo-Octofuranuronic acid, 4-C-(acetyloxy)-3,6-anhydro-5-deoxy-6-C-(methoxycarbonyl)-, methyl ester, 1-acetate 2,7-dibenzoate (9CI)
• L-glycero-α-D-allo-Octofuranuronic acid, 4-C-(acetyloxy)-3,6-anhydro-5-deoxy-6-C-(methoxycarbonyl)-, methyl ester, 1-acetate 2,7-dibenzoate (9CI)
• β-L-threo-Pentofuranose, 4-C-(acetyloxy)-5-deoxy-5-fluoro-1,2-O-(1-methylethylidene)-, 4-methylbenzenesulfonate, (4ξ)- (9CI)
• α-D-Glucopyranoside, methyl 6-deoxy-4-O-(4-C-hydroxy-2,3,5-tri-O-methyl-α-D-arabinofuranosyl)-2,3-di-O-methyl-6-[[(4-nitrophenyl) sulfonyl]amino]-
• Spiro[furo[3,4-d]-1,3-dioxole-4(3aH),5′(4′H)-isoxazole], 6,6a-dihydro-6-methoxy-2,2-dimethyl-3′-[(3aR,4R,6R,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro[3,4-d]-1,3-dioxol-4-yl]-, (3aS,4R,6R,6aR)
• Spiro[furo[3,4-d]-1,3-dioxole-4(3aH),2′(3′H)-pyrrolo[1,2-b]isoxazole], hexahydro-6-methoxy-4′,5′-bis(methoxymethoxy)-2,2-dimethyl-, (2′R,3aS,3′aS,4′S,5′S,6R,6aR)-
• 5,2,9-Ethanylylidene-1-benzoxepin-8,11(2H)-dione, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-2-yl]-6-[(2S,3S)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-2-yl]-5,5a,9,9a-tetrahydro-2,9,9a,10-tetrahydroxy-, (2R,5S,5aS,9S,9aS,10R)- (9CI)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′a H)-furo[2,3-d][1,3]dioxol]-6′-ol, 3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethyl-, 6′-acetate, (3aR,3′aS,5S,6′S,6′aR,8aR)-
• Spiro[furo[3,4-d)-1,3-dioxole-4(3aH),5′(4′H)-isoxazole], 6,6a-dihydro-6-methoxy-2,2-dimethyl-3′-phenyl-, (3aS,4R,6R,6aR)-
• 1,4-Epoxycyclobuta[5,6]-p-dioxino[2,3-d)-o-dioxin, 1,4,4a,5a,7a,8a-hexahydro-1,4,4a,5a,6,7,7a,8a-octamethyl-, stereoisomer (8CI)
• 1,4-Epoxycyclobuta[5,6]-p-dioxino[2,3-d)-o-dioxin, 1,4,4a,5a,7a,8a-hexahydro-1,4,4a,5a,6,7,7a,8a-octamethyl-, stereoisomer (8CI)
• Spiro[furo[3,4-d)-1,3-dioxole4(3aH),6′-[6H]1,2]oxazine]-3′-carboxylic acid, hexahydro-6-methoxy-2,2-dimethyl-, ethyl ester, (3′ R,3a5,4R,6R,6aR)-
• Spiro[furo[3,4-d)-1,3-dioxole-4(3aH),5′-isoxazolidine], dihydro-6-methoxy-2,2-dimethyl-2′-(phenylmethyl)-, (3aS,4R,6R,6aR)-
• 2H-Naphtho[1,2-b]pyran-2-one, 7-(acetyloxy)-3-methyl-6-[[1,3,4,6-tetra-O-acetyl-5-C-[(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)oxy]-β-D-fructofuranosyl]oxy]-
• Spiro[furo[3,4-d)-1,3-dioxole-4(3aH),5′(4′H)-isoxazole), 6,6a-dihydro-6-methoxy-2,2-dimethyl-3′-(4-methylphenyl)-, (3aS,4R,6R,6aR)-
• 3,6-Epoxy-2H,8H-pyrimido[6,1-b][1,3]-oxazocine-8,10(9H)-(dione, 3,4,5,6-tetrahydro-4-hydroxy-, acetate (ester)(7CI)
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6′-ol, octahydro-2,2,2′,2′-tetramethyl-, 6′-benzoate, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-
• Spiro[5H-1,3-dioxolo[4,5][furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d) [1,3]dioxol]-6′-ol, octahydro-2,2,2′,2′-tetramethyl-6′-(nitromethyl)-, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-
• Spiro[furo[3,4-d)-1,3-dioxole-4(3aH),6-[16H]1,2]oxazine]-3′-carboxylic acid, 4′,5′,6,6a-tetrahydro-6-methoxy-2,2-dimethyl-, ethyl ester, (3aS,4R,6R,6aR)-
• Hexanoic acid, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-octahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-yl ester
• Acetamide, N-[1-[(2′R,3′R,3aS,3′aS,5′S,6S,6aR,7′aR)-2′,3′-bis(acetyloxy)-2′,3′,3′a,6,6′,6a,7′,7′a-octahydro-6-hydroxy-2,2-dimethylspiro[furo[2,3-d]-1,3-dioxole-5 (3aH),5′-[5H]furo[3,2-b]pyran]-6-yl]ethyl]-
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6′-ol, 3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethyl-6′-(nitromethyl)-, (3aR,3′aS,5S,6′S,6′aR,8aR)-
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d)[1,3]dioxol]-6′-ol, 3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethyl-, 6′-benzoate, (3aR,3′aS,5S,6′S,6′aR,8aR)-
• Spiro[furo[3,4-d)-1,3-dioxole-4(3aH),5′(4′H)-isoxazole], 3′-(2,6-dichlorophenyl)-6,6a-dihydro-6-methoxy-2,2-dimethyl-, (3aS,4R,6R,6aR)-
• 1,6,11,14,16,20,23,24-Octaoxahexaspiro[3.0.3.0.0.4.0.3.0.3.1.1]tetracosane
• Hexanoic acid, (3aR,3′aS,5S,6′S,6′aR,8aR)-3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3)dioxol]-6′-yl ester
• Benzoic acid, 4-chloro-, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-octahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-yl ester
• Benzoic acid, 4-bromo-, (3aR,3′aS,3bS,5S,6′S,6′aR,7aR,8aR)-octahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-yl ester
• Spiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-ol, 3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethyl-6′-(1-nitroethyl)-, (3′aS,3aR,5S,6′S,6′aR,8aR)-
• Sorbofuranose, 2,3:4,6-di-O-isopropylidene-, p-toluenesulfonate, α-L-(7CI)
• Benzoic acid, 4-chloro-, (3aR,3′aS,5S,6′S,6′aR,8aR)-3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-yl ester
• Benzoic acid, 4-bromo-, (3aR,3′aS,5S,6′S,6′aR,8aR)-3a,6,6′,6′a,7,8a-hexahydro-2,2,2′,2′-tetramethylspiro[5H-1,3-dioxolo[4,5]furo[3,2-b]pyran-5,5′(3′aH)-furo[2,3-d][1,3]dioxol]-6′-yl ester
• Spiro[furo[2,3-d]-1,3-dioxole-5 (3aH),6′-[6H]1,2]oxazine]-3′-carboxylic acid, hexahydro-2,2-dimethyl-6-(phenylmethoxy)-, ethyl ester, (3′R,3aS,5R,6R,6aR)-
• Spiro[furo[3,4-d]-1,3-dioxole-4(3aH),6′-[6H-1,2]oxazine]-2′,3′(3′H)-dicarboxylic acid, tetrahydro-6-methoxy-2,2-dimethyl-, 2′-(1,1-dimethylethyl) 3′-ethyl ester, (3′R,3aS,4R,6R,6aR)-
• Spiro[furo[2,3-d]-1,3-dioxole-5(3aH),6′-[6H]1,2]oxazine]-3′-carboxylic acid, 4′,5′,6,6a-tetrahydro-2,2-dimethyl-6-(phenylmethoxy)-, ethyl ester, (3aS,5R,6R,6aR)-
• β-D-Galactofuranose, 3,4-O-[(acetylamino)phenylmethylene]-4-C-hydroxy-, 1-acetate 2,5,6-tribenzoate (9CI)
• β-D-Galactofuranose, 3,4-O-[(2,5-dioxo-1-pyrrolidinyl)phenylmethylene]-4-C-hydroxy-, 1-acetate 2,5,6-tribenzoate (9CI)
• Osmium, tetraoxotetrakis(pyridine)[μ-[1-(tetrahydro-2,3,4,5-tetrahydroxy-2-furanyl) ethanonato(4-)]]di-, stereoisomer (9CI)
• β-D-Galactofuranose, 3,4-O-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenylmethylene]-4-C-hydroxy-, 1-acetate 2,5,6-tribenzoate (9CI)
• Piperazinone, 4-[(dihydro-2,2,6,6-tetramethylfuro[2,3-d;4,5-d]bis[1,3]dioxol-3a(4aH)-yl) carbonyl]-6-ethyl-1-[(4-methylphenyl)methyl]- (9CI)
• Quinoline, 5,7-dichloro-1-[(dihydro-2,2,6,6-tetramethylfuro[2,3-d:4,5-d]bis[1,3]dioxol-3a(4aH)-yl) carbonyl]-4-(4-fluorophenoxy)-1,2-dihydro-(9CI);
• or a combination thereof.

A method of reducing a population of pathogenic microorganisms on a surface, the method comprising applying to the surface a composition comprising:

• (a) one or more germinants;
• (b) polyolprepolymer-2 or poly(styrene-co-maleic anhydride) copolymers (SMA);
• (c) one or more nanoscale particle having a particle size of about 5 nm to about 200 nm;
• and (d) a carrier.