Method for the induction of an immune response
AssigneeNetwork Immunology Inc.
InventorsGeoffrey W. Hoffmann, Sybille Muller
Life of this patent
Estimating the term…
Abstract
An immune response against an antigen is induced by stimulation with a two-component vaccine that includes an antiidiotypic antibody as one of the components. An immune response against an antigen is also induced by stimulation with other two-component vaccines. Stimulation by a two-component vaccine may be followed by stimulation with a monoclonal broadly neutralizing anti-HIV antibody or with one of the components of the two-component vaccine. This method of inducing immunity has applications in vaccines against infectious pathogens and in therapeutic and preventive vaccines against cancers.
Claims26
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) obtaining Ag-specific antibodies;
- b) producing monoclonal antiidiotypic antibodies specific for the said Ag-specific antibodies;
- c) producing complexes and/or mixtures of (a) said monoclonal antiidiotypic antibodies and (b) the antigen Ag;
- d) immunizing the vertebrate A with the said complexes or mixtures.
A method for immunizing a vertebrate “A” against infection with a pathogen comprising:
- a) obtaining pathogen-specific antibodies from a vertebrate “B” that has been immunized with or infected by the pathogen, or immunized with pathogen antigen or antigens;
- b) producing monoclonal antiidiotypic antibodies specific for the said pathogen-specific antibodies;
- c) producing complexes and/or mixtures of (a) said monoclonal antiidiotypic antibodies and (b) the corresponding pathogen antigen or antigens;
- d) immunizing the vertebrate A with the said complexes or mixtures.
A method for the treatment or prevention of a cancer, said method comprising:
- a) obtaining cancer antigen-specific antibodies from a vertebrate that has been immunized with the cancer antigen-specific antigen or antigens;
- b) producing monoclonal antiidiotypic antibodies specific for the cancer-specific antibodies;
- c) producing complexes and/or mixtures of (i) monoclonal antiidiotypic antibodies and (ii) the corresponding cancer antigen or antigens;
- d) immunizing a vertebrate with the said complexes and/or mixtures.
A kit comprising:
- a) complexes and/or mixtures of a monoclonal antiidiotypic antibody and the corresponding antigen and a pharmaceutically acceptable carrier;
- and
- b) instructions for use.
A pharmaceutical composition comprising a monoclonal antiidiotypic antibody complexed to and/or mixed with the corresponding antigen, and a pharmaceutically acceptable carrier.
Use of a monoclonal antiidiotypic antibody complexed to and/or mixed with the corresponding antigen as a vaccine against an infectious agent.
Use of a monoclonal antiidiotypic antibody complexed to and/or mixed with the corresponding antigen as a therapeutic vaccine against a cancer.
Use of a monoclonal antiidiotypic antibody complexed to and/or mixed with the corresponding antigen as a preventive vaccine against a cancer.
A method for immunizing a vertebrate “A” against an infectious agent that causes chronic infection comprising:
- a) producing complexes and/or mixtures of (i) 1F7 and (ii) an antigen of the infectious agent;
- and
- b) immunizing the vertebrate A with the said complexes or mixtures.
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) obtaining Ag-specific antibodies from a vertebrate “B” that has been immunized with Ag;
- b) producing monoclonal antiidiotypic antibodies specific for the said Ag-specific antibodies;
- c) producing complexes and/or mixtures of (i) said monoclonal antiidiotypic antibodies and (ii) the antigen Ag;
- d) immunizing the vertebrate A with the said complexes and/or mixtures;
- and
- e) immunizing the vertebrate with a broadly neutralizing monoclonal anti-HIV antibody.
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) obtaining Ag-specific antibodies from a vertebrate “B” that has been immunized with Ag;
- b) producing monoclonal antiidiotypic antibodies specific for the said Ag-specific antibodies;
- c) producing a two-component vaccine comprising complexes and/or mixtures of (i) said monoclonal antiidiotypic antibodies and (ii) the antigen Ag;
- d) immunizing the vertebrate A with the said complexes and/or mixtures;
- and
- e) immunizing the vertebrate with one of the components of the two-component vaccine.
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) obtaining Ag-specific antibodies from a vertebrate “B” that has been immunized with Ag;
- b) producing monoclonal antiidiotypic antibodies specific for the said Ag-specific antibodies;
- c) producing mixtures and/or complexes of (i) said monoclonal antiidiotypic antibodies and (ii) a monoclonal broadly neutralizing anti-HIV antibody;
- d) immunizing the vertebrate A with the said complexes and/or mixtures;
- and
- e) immunizing the vertebrate with a broadly neutralizing monoclonal anti-HIV antibody.
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) obtaining Ag-specific antibodies from a vertebrate “B” that has been immunized with Ag;
- b) producing monoclonal antiidiotypic antibodies specific for the said Ag-specific antibodies;
- c) producing mixtures and/or complexes of (i) said monoclonal antiidiotypic antibodies and (ii) a monoclonal broadly neutralizing anti-HIV antibody;
- d) immunizing the vertebrate A with the said mixtures and/or complexes;
- and
- e) immunizing the vertebrate with the monoclonal antiidiotypic antibody.
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) producing complexes and/or mixtures of (i) an antibody Ab and (ii) the antigen Ag;
- b) immunizing the vertebrate A with the said complexes and/or mixtures;
- and
- c) immunizing the vertebrate with a broadly neutralizing monoclonal anti-HIV
A method for inducing an immune response in a vertebrate “A” to an antigen Ag comprising:
- a) producing complexes and/or mixtures of (i) an antibody Ab and (ii) the antigen Ag;
- b) immunizing the vertebrate A with the said complexes and/or mixtures;
- and
- c) immunizing the vertebrate with the antigen Ag or the antibody Ab.
A kit comprising:
- a) a two-component vaccine and a pharmaceutically acceptable carrier;
- b) a monoclonal broadly neutralizing anti-HIV antibody and a pharmaceutically acceptable carrier;
- c) one of the two components of said two-component vaccine and a pharmaceutically acceptable carrier;
- and
- d) instructions for use.
Dependencies are inferred from the claim text.