Compositions and methods of enhancing immune responses to eimeria
AssigneesBoard of Trustees of the University of Arkansas, The Texas A&M University System, University of Guelph
InventorsWalter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
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Abstract
Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
Claims42
A vaccine comprising a vector comprising a first polynucleotide sequence encoding a thrombospondin-related anonymous protein (TRAP) polypeptide of SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3 or an immunogenic fragment thereof comprising at least six consecutive amino acids of SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3.
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Dependencies are inferred from the claim text.