Cytochrome p450 suicide gene system
OwnerHelmut Hanenberg, Constanze Wiek +2inventors
InventorsHelmut Hanenberg, Constanze Wiek, Christof Kramm, Eva Schmidt
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Abstract
The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a nucleic acid encoding for a modified human CYP4B1 protein, as well as to a cell comprising a modified CYP4B1 protein. In addition, the invention relates to a modified human CYP4B1 protein for use in treating transplantation induced graft-versus-host-disease (GvHD), and to 4-ipomeanol (4-IPO) for use in killing a cell.
Claims20
A modified human CYP4B1 protein with a serine to proline exchange in a meander region, wherein a 5′-region, a middle region, a 3′-region of the human CYP4B1 protein and/or a part of any of the regions is replaced by a corresponding part of a CYP4B1 protein of a different species.
A modified human CYP4B1 protein, wherein at least one part of the human CYP4B1 protein is replaced by a corresponding part of a CYP4B1 protein of a different species.
Dependencies are inferred from the claim text.