Immunoglobulin reduced in thrombogenic agents and preparation thereof
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsRoni Mintz, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meidler
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Abstract
The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
Claims39
A method for removing a thrombogenic agent from an immunoglobulin containing solution, the method comprising the steps of:
- providing the immunoglobulin containing solution at a pH in the range of higher than 3.8 to equal to or lower than 5.3;
- providing a support comprising immobilized negatively charged groups;
- contacting the solution with the support;
- and collecting an unbound fraction I.
38-51. (canceled)
A method for treating a subject suffering from an immunodeficiency, an inflammatory disease, an autoimmune disease, or an acute infection, comprising administering to the subject an effective amount of an immunoglobulin composition according to claim 50.
Dependencies are inferred from the claim text.