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AssigneeAbbVie Inc.
InventorsRobert K. Hickman, Qing Huang, Cheryl L. Weed, Scott T. Ennis, Barbara Perilli-Palmer, Min Wan
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Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
A pharmaceutical grade preparation comprising adalimumab, wherein the adalimumab is purified from a fermentation harvest of cultured cells expressing adalimumab by a method comprising:
A pharmaceutical grade preparation comprising adalimumab, wherein the adalimumab is purified from a fermentation harvest of cultured cells expressing adalimumab by a method comprising:
Dependencies are inferred from the claim text.