2,3-benzodiazepines

Compounds of the general formula I

• in which
• X represents an oxygen or sulphur atom, and
• A represents a monocyclic heteroaryl ring which has 5 or 6 ring atoms or represents a phenyl ring, and
• R1a represents hydrogen, halogen, cyano, carboxyl, amino or aminosulphonyl,
• or
• represents a C1-C6-alkoxy, C1-C3-alkoxy-C1-C3-alkyl, C1-C3-alkoxy-C2-C3-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylamino-C1-C6-alkyl, N-(heterocyclyl)-C1-C6-alkyl, N-(heterocyclyl)-C1-C6-alkoxy, hydroxy-C1-C6-alkyl, hydroxy-C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkylcarbonyl or C1-C6-alkoxycarbonyl radical,
• or
• represents a monocyclic heterocyclyl radical which has 3 to 8 ring atoms and may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, cyano, nitro, hydroxy, amino, oxo, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, hydroxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl, phenyl, halophenyl, phenyl-C1-C6-alkyl, pyridinyl, —NR6C(═O)—R9, —C(═O)—NR6R7, —C(═O)—R8, —S(═O)2—NR6R7, —S(═O)—R9, —S(═O)2—R9, —NH—S(═O)2—R9, and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms,
• or
• represents a monocyclic heteroaryl radical which has 5 or 6 ring atoms and may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, hydroxy, amino, cyano, nitro, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl, —C(═O)—NR6R7, —C(═O)—R8, —S(═O)2—NR6R7, —S(═O)—R9, —S(═O)2—R9, —NH—S(═O)2—R9, and/or by a monocyclic heterocyclyl radical which has 3 to 8 ring atoms, and/or by a monocyclic heteroaryl radical which has 5 or 6 ring atoms, and/or by a rhenyl radical which for its part may optionally be mono- or polysubstituted by halogen, C1-C3-alkyl and/or C1-C3-alkoxy,
• or
• represents a phenyl radical which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, cyano, nitro, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, —C(═O)NR6R7, —C(═O) R8, C1-C3-alkylsulphinyl, C1-C3-alkylsulphonyl, —S(═O)2NH2, C1-C3-alkylsulphonylamino, C1-C3-alkylaminosulphonyl, C3-C6-cycloalkylaminosulphonyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, hydroxy-C1-C6-alkyl, C3-C10-cycloalkyl, and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms, and/or a monocyclic heteroaryl radical which has 5 or 6 ring atoms and which for its part may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, C1-C3-alkyl and C1-C3-alkoxy, and
• R1b and R1c independently of one another represent hydrogen, halogen, hydroxy, cyano, nitro and/or represent a C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl radical and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms, and
• R2 represents a C1-C3-alkyl or trifluoromethyl or a C3- or C4-cycloalkyl radical, and
• R3 represents cyclopropyl, C1-C3-alkyl, C1-C3-alkoxy, amino, cyclopropylamino or C1-C3-alkylamino, and
• R4 and R5 independently of one another represent hydrogen, hydroxy, cyano, nitro, amino, aminocarbonyl, fluorine, chlorine, bromine, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl or C1-C6-alkylaminosulphonyl,
• or
• represent C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl or C1-C6-alkylaminosulphonyl which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, carboxyl, hydroxy-C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, monocyclic heterocyclyl which has 3 to 8 ring atoms and/or monocyclic heteroaryl which has 5 or 6 ring atoms, where the monocyclic heterocyclyl and heteroaryl radicals mentioned for their part may optionally be monosubstituted by C1-C3-alkyl,
• or
• represent C3-C10-cycloalkyl which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms,
• or
• represent monocyclic heteroaryl which has 5 or 6 ring atoms and which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, cyano, nitro, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, hydroxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl, —C(═O) R8, —S(═O)2R9, —NR6R7, and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms,
• or
• represent monocyclic heterocyclyl which has 3 to 8 ring atoms and which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, cyano, oxo, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl, —C(═O) R8, —S(═O)2R9, —NR6R7, and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms,
• or
• represent phenyl which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, cyano, nitro, carboxyl, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, C1-C6-alkylaminocarbonyl, C1-C6-alkylaminosulphonyl, C1-C6-alkylamino-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl and/or a monocyclic heterocyclyl radical which has 3 to 8 ring atoms, and
• R6 and R7 independently of one another represent hydrogen, C1-C3-alkyl, cyclopropyl, di-C1-C3-alkyl-amino-C1-C3-alkyl or fluoropyridyl, and
• R8 represents hydroxy, C1-C6-alkyl, halo-C1-C3-alkyl, hydroxy-C1-C3-alkyl, C1-C3-alkoxy-C1-C3-alkyl, C3-C8-cycloalkyl, phenyl, monocyclic heterocyclyl which has 3 to 8 ring atoms or monocyclic heteroaryl which has 5 or 6 ring atoms, where phenyl, heteroaryl and heterocyclyl may optionally be mono- or disubstituted by halogen, C1-C3-alkoxy or C1-C3-alkyl, and
• R9 represents hydrogen, C1-C6-alkyl or C1-C4-alkoxy,
• and their polymorphs, enantiomers, diastereomers, racemates, tautomers, solvates, physiologically acceptable salts and solvates of these salts,
• with the proviso that,
• if A represents a phenyl ring and R4 and R5 independently of one another represent hydrogen, hydroxy, cyano, nitro, amino, aminocarbonyl, fluorine, chlorine, bromine, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylamino-carbonyl or C1-C6-alkylaminosulphonyl, or represent C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl or C1-C6-alkylaminosulphonyl which may optionally be mono- or polysubstituted by identical or different substituents from the group consisting of halogen, amino, hydroxy, carboxyl, hydroxy-C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylamino, amino-C1-C6-alkyl, monocyclic heterocyclyl which has 3 to 8 ring atoms and/or monocyclic heteroaryl which has 5 or 6 ring atoms, where the monocyclic heterocyclyl and heteroaryl radicals mentioned for their part may optionally be monosubstituted by C1-C3-alkyl,
• R1a does not represent hydrogen, halogen, cyano, carboxyl, amino or aminosulphonyl, or represent a C1-C6-alkoxy, C1-C3-alkoxy-C1-C3-alkyl, C1-C3-alkoxy-C2-C3-alkoxy, C1-C6-alkylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylamino-C1-C6-alkyl, N-(heterocyclyl)-C1-C6-alkyl, N-(heterocyclyl)-C1-C6-alkoxy, hydroxy-C1-C6-alkyl, hydroxy-C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkylcarbonyl or C1-C6-alkoxycarbonyl radical, and where the proviso does not encompass those compounds of the general formula (I) in which
• A is phenyl and R4 is hydrogen, fluorine, chlorine or bromine and R5 is C1-C6-alkoxy which is substituted one or more times by identical or different halogens, and R1a is halogen,
• and also not those compounds of the general formula (I) in which A is phenyl and
• R4 is hydrogen and R5 is C1-C6-alkoxy which is substituted one or more times by identical or different monocyclic heterocyclyl radicals having 3 to 8 ring atoms and/or monocyclic heteroaryl radicals having 5 or 6 ring atoms, it being possible for the stated monocyclic heterocyclyl and heteroaryl radicals in turn to be optionally monosubstituted by C1-C3-alkyl, and R1a is halogen.