Loading patent…
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsJessica Zucman-Rossi, Aurélien DE REYNIES, David RICKMAN, Sandrine BOYAULT
Estimating the term…
Methodology for the in vitro classification and/or prognosis of hepatocellular carcinoma (HCC) from a HCC sample is based on the determination of the expression profile of particular gene combinations. For example, in one embodiment, a method comprises measuring the expression level in an HCC sample of at least 8 genes selected from the group consisting of: RAB1A, REG3A, NRAS, RAMP3, MERTK, PIR, EPHA1, LAMA3, G0S2, HN1, PAK2, AFP, CYP2C9, CDH2, HAMP, SAE1, ADH6, DCN, FLJ10159, ALDH1L1, IGF1, LECT2, SLC38A1, SPARCL1, CTNNA2, GLUL, LEF1, MATN2, MME, PFN2, SPINT2, TBX3, and FGFR2; b) calculating 6 subgroup distances from the expression profile; and c) classifying the HCC tumor in the subgroup for which the subgroup distance is the lowest, wherein the 6 subgroups G1, G2, G3, G4, G5, and G6 are defined by the presence (+) or absence (−) of their clinical and genetic features.
-25. (canceled)
A method of in vitro prognosis of global survival and/or survival without relapse of a subject suffering from HCC, comprising:
A kit for the in vitro prognosis of global survival and/or survival without relapse from a liver HCC sample of a subject suffering from HCC, comprising reagents for the determination of an expression profile comprising a combination of TAF9 at least one gene selected from the group consisting of NRCAM, PIR, RAMP3, SLC21A2, TNA, HN1, PSMD1, MRPS7, CDC20, ENO1, HLF, STRA13, RAGD, NRAS, ARFGEF2, RAB1A, G0S2, SMAD3, DNAJA3, HELO1, RHOQ, C14orf156, NPEPPS, PDCD2, PHB, KIAA0090, IMP-3, KPNA2, KIAA0268, UNQ6077, LOC440751, G6PD, STK6, TFRC, GLA, TRIP13, SPP1, AKR1C1, AKR1C2, GIMAP5, ADM, CCNB1, TKT, AGPS, RAN, NUDT9, HRASLS3, HLA-DQA1, NEU1, RARRES2, PAPOLA, ABCB6, BIRC5, FLJ20273, C14orf109, CHKA, TUBB2, HMGB3, TXNRD1, IFITM1, KIAA0992, MPPE1, KLRB1, CCL5, SYNE1, DNASE1L3, CYP2C18, PACSIN2, PON3, and PPP2R1B.
Dependencies are inferred from the claim text.