Loading patent…
AssigneesGlykos Finland Oy, Novartis AG
InventorsJari Natunen, Ann Westerholm-Parvinen, Hanna Salo, Jussi Joensuu, Heli Viskari, Christopher Landowski, Anne Huuskonen, Anne Kanerva, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Juhani Saarinen, Markku Saloheimo
Estimating the term…
Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.
A filamentous fungal cell comprising at least a mutation that reduces an endogenous protease activity compared to a parental filamentous fungal cell which does not have the mutation, and further comprising a polynucleotide encoding a polypeptide having fucosyltransferase activity.
Dependencies are inferred from the claim text.