Modulation of enhancer rna mediated gene expression
AssigneesThe Regents of the University of California, Isis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Christopher K. Glass, Michael G. Rosenfeld, Wenbo Li, Michael T. Lam
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Abstract
Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.
Claims87
A method of inhibiting gene expression in a cell comprising contacting the cell with a specific inhibitor of an enhancer RNA (eRNA), thereby inhibiting expression of one or more genes in the cell.
A compound comprising a specific inhibitor of a MMP9 enhancer RNA (eRNA), wherein said MMP9 eRNA comprises the nucleic acid sequence of SEQ ID NO:1.
A compound comprising a specific inhibitor of a CX3CR1 eRNA.
A compound comprising a specific inhibitor of a CA12, FOXC1, GREB1, P2RY2, SMAD7, PGR, SIAH2, NRIP1, TFF1, or KCNK5 eRNA.
Dependencies are inferred from the claim text.