Therapeutic agent for epithelial and endothelial injury
AssigneeNihon University
InventorsChiaki Hidai, Hisataka Kitano, Atsushi Mamiya
Life of this patent
Estimating the term…
Abstract
The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22.
Claims13
A peptide of any one of the following (a) to (f), a derivative thereof, or their salt:
- (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 10, 4, 12 and 6;
- (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 16, 18, 20 and 22;
- (c) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells;
- (d) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells;
- (e) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells;
- and
- (f) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells.
A therapeutic agent for epithelial and endothelial injury, which comprises a peptide of any one of the following (a) to (f), a derivative thereof, or their salt:
- (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 10, 4, 12 and 6;
- (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 16, 18, 20 and 22;
- (c) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury;
- (d) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury;
- (e) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury;
- and
- (f) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury.
A spread inducer of epithelial and endothelial cells, which comprises a peptide of any one of the following (a) to (f), a derivative thereof, or their salt:
- (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 10, 4, 12 and 6;
- (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS:
- 16, 18, 20 and 22;
- (c) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of inducing spread of epithelial and endothelial cells;
- (d) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of inducing spread of epithelial and endothelial cells;
- (e) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of inducing spread of epithelial and endothelial cells;
- and
- (f) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of inducing spread of epithelial and endothelial cells.
Dependencies are inferred from the claim text.