Multifunctional Antibodies Binding to EGFR and MET
AssigneeEli Lilly and Company
InventorsHector ALDAZ, Barrett ALLAN, Ling LIU, Jirong LU, Ying TANG, Sheng-Hung Rainbow TSCHANG, Pia Pauliina YACHI
Life of this patent
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Abstract
Provided are multifunctional antibodies, and/or antigen-binding fragments, that bind to, and inhibit the activity of, both human epidermal growth factor receptor (EGFR) and MET, and that are effective in treating cancers and other diseases, disorders, or conditions where pathogenesis is mediated by EGFR and MET.
Claims20
A multifunctional antibody that binds MET and EGFR comprising:
- (a) two first polypeptides wherein both first polypeptides comprise the amino acid sequence of SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 29, SEQ ID NO:
- 31, or SEQ ID NO:
- 52;
- and
- (b) two second polypeptides wherein both second polypeptides comprise the amino acid sequence of SEQ ID NO:
- 33.
A DNA molecule comprising a polynucleotide encoding a polypeptide having the amino acid sequence of SEQ ID NO:
- 27, SEQ ID NO:
- 29, or SEQ ID NO:
- 31.
A DNA molecule comprising a polynucleotide encoding a polypeptide having the amino acid sequence of SEQ ID NO:
- 23.
A DNA molecule comprising:
- (a) a polynucleotide encoding a polypeptide having the amino acid sequence of SEQ ID NO:
- 27;
- and
- (b) a polynucleotide encoding a polypeptide having the amino acid sequence of SEQ ID NO:
- 33.
Dependencies are inferred from the claim text.