Binding molecules targeting pathogens
AssigneeApo-T B.V.
InventorsJohan Renes, Paul Steverink, Ralph Alexander Willemsen
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Abstract
A first aspect of the disclosure relates to the field of binding molecules targeted at pathogens. The disclosure further relates to proteinaceous binding molecules targeting cells displaying pathogen-associated molecular patterns, in particular targeting cell surface molecules associated with or derived from pathogens, more in particular cell surface proteins displaying peptides from intracellular (pathogen associated) proteins.
Claims20
A proteinaceous molecule comprising:
- at least two specific binding domains separated by at least one linker,
- wherein said proteinaceous molecule comprises a single polypeptide chain, and wherein said binding domains specifically recognize binding sites present on or associated with at least one pathogen or a cell infected with a pathogen.
A method of treating a subject suffering from an infectious disease, the method comprising:
- administering to the subject a proteinaceous molecule comprising at least four specific binding domains for the same binding site separated by at least one linker, wherein said proteinaceous molecule comprises a single polypeptide chain so as to treat the subject for the infectious disease.
A proteinaceous molecule according to FIG. 1, FIG. 2 or FIG. 3.
A proteinaceous molecule comprising:
- at least three specific binding domains for different binding sites separated from each other by at least one linker, wherein the binding domains specifically recognize binding sites present on or associated with at least one pathogen or a cell infected with a pathogen, and
- an effector moiety,
- wherein the proteinaceous molecule comprises a single polypeptide chain.
Dependencies are inferred from the claim text.