Human antibodies against pseudomonas aeruginosa lps derived from transgenic xenomouse
AssigneeCase Western Reserve University
InventorsJohn R. SCHREIBER, Kulwant Kamboj KAUR
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Abstract
The invention described herein provides for human antibodies produced in non-human animals that specifically bind to Pseudomanas aeruginosa Lipopolysaccharide (LPS). The invention further provides methods for making the antibodies in a non-human animal, expression of the antibodies in cell lines including hybridomas and recombinant host cell systems. Also provided are kits and pharmaceutical compositions comprising the antibodies and methods of treating or preventing pseudomonas infection by administering to a patient the pharmaceutical compositions described herein.
Claims2
The hybridoma cell line that produces C3 monoclonal antibody, said hybridoma cell line having American Type Culture Collection Accession Number PTA-4075.
A method of producing monoclonal antibody reactive to Pseudomonas aeruginosa, the method comprising cultivation of the hybridoma cell line having American Type Culture Collection Accession Number PTA-4075.
Dependencies are inferred from the claim text.