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AssigneeCrucell Holland B.V.
InventorsMark Throsby, Robert H.E. Friesen, Theodorus H.J. Kwaks, Mandy A. C. Jongeneelen
Estimating the term…
Described are binding molecules, e.g., human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, e.g., H3N2, and have a broad neutralizing activity against such influenza virus. Described are polynucleotides encoding the binding molecules, their sequences and compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of influenza virus H3N2 infection. The binding molecules may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
An isolated human binding molecule able to specifically recognize and bind to an epitope in influenza hemagglutinin protein (HA), having neutralizing activity against influenza viruses comprising HA of the H3 subtype and having cross-neutralizing activity against at least an influenza virus comprising HA of the H7 subtype, and/or an influenza virus comprising HA of the H10 subtype.
A non-naturally occurring peptide of the type comprising a heavy chain CDR1 region, a heavy chain CDR2 region, and a heavy chain CDR3 region, said peptide being able to specifically bind to an epitope in influenza hemagglutinin protein (HA), wherein said peptide has neutralizing activity against influenza viruses comprising HA of the H3 subtype and having cross-neutralizing activity against at least an influenza virus comprising HA of the H7 subtype, and/or an influenza virus comprising HA of the H10 subtype.
A composition comprising:
A pharmaceutical composition comprising at least two influenza virus neutralizing binding molecules, wherein at least one binding molecules is able to neutralize influenza viruses comprising HA of the H1 and/or H5 subtype, and wherein at least one binding molecule is able to neutralize influenza viruses comprising HA of the H3, H7 and/or H10 subtype.
A host comprising at least one vector of claim 28.
Dependencies are inferred from the claim text.