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US 2015/0175666 A1Published application
Peptides derived from hiv gp41 for treating t-cell mediated pathologies
AssigneeYeda Research and Development Co. Ltd.
InventorsYechiel Shai, Avraham Ashkenazi, Omri Faingold, Avraham Ben Nun, Nathali Kaushansky
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Abstract
The present invention provides peptides, derivatives and analogs comprising an amino acid sequence HTTWMEWD (SEQ ID NO: 1) derived from the ectodomain of HIV gp41 protein, pharmaceutical compositions comprising same, and uses thereof for therapy of T-cell mediated diseases and disorders.
Claims21
An isolated peptide of 10-30 amino acids comprising the amino acid sequence WNHTTWMEWD as set forth in SEQ ID NO:
- 2, or an analog thereof comprising at least one D amino acid.
An isolated peptide of 8-30 amino acids comprising the amino acid sequence HTTWMEWD as set forth in SEQ ID NO:
- 1, or an analog or a salt thereof, wherein the analog is selected from an analog comprising at least on D amino acid or an analog comprising a substitution of at least one Trp (W) residue with an amino acid selected from Ile (I), Leu (L) and Gly (G).
Dependencies are inferred from the claim text.