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US 2015/0175656 A1Published application
Crystalline tripeptide epoxy ketone protease inhibitors
AssigneeOnyx Therapeutics, Inc.
InventorsPhiasivongsa Pasit, Louis C. Sehl
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Abstract
The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
Claims23
A method for preparing a crystalline compound of Formula (II)
- comprising (i) preparing a solution of a compound of Formula (II) in an organic solvent;
- (ii) bringing the solution to supersaturation to cause formation of crystals;
- and (iii) isolating the crystals.
A crystalline compound having a structure of Formula (II)
A method for the preparation of a crystalline compound of Formula (II),
- comprising (i) reacting a compound of Formula (III)
- wherein X is any suitable counterion, with a compound of Formula (IV) in a second organic solvent
- (ii) preparing a solution of a compound of Formula (II) in the second organic solvent;
- (iii) bringing the solution to supersaturation to permit formation of crystals;
- and (iv) isolating the crystals to provide a crystalline compound of Formula (II).
2 more elements
Dependencies are inferred from the claim text.