Substituted pyrazoles and uses thereof

A compound of formula 0:

• and salts thereof;
• wherein in formula 0
• R1A is selected from the group consisting of H, —F, —Cl, a 3 to 12 membered heterocycloalkyl, 5 or 6 membered) heteroaryl, —(X1A)0-1—OR1A-1, —(X1A)0-1—SR1A-1, —(X1A)0-1—S(O)R1A-1, —(X1A)0-1—S(O)2R1A-1 and —(X1A)0-1—N(R1A-1)2, each X1A is independently selected from the group consisting of C1-4 alkylene, C1-4 haloalkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene, R1A-1 at each occurrence is each independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 heteroalkyl, 3-7 membered cycloalkyl, 3-7 membered cycloalkyl-C1-4 alkyl-, 3-7 membered heterocycloalkyl, 3-7 membered heterocycloalkyl-C1-4 alkyl-, 5-6 membered heteroaryl, 5-6 membered heteroaryl-C1-4 alkyl-, phenyl and phenyl-C1-4 alkyl-, or any two R1A-1 groups attached to the same nitrogen atom are optionally combined to form a 3 to 6 membered heterocyclic ring optionally comprising 1 to 2 additional heteroatom selected from N, O and S, and wherein a R1A group at each occurrence is independently optionally further substituted with 1 to 5 R1A-2 substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, —CN, —NO2, —SF5, —NH2, C1-6 alkoxy, C1-6 alkylamino, C1-6 dialkylamino, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, oxo, —S(═O)1-2—C1-6 alkyl and 3 to 7 membered heterocycloalkyl;
• R1B is selected from the group consisting of H, —OH, —F, —Cl, —Br, —I, —CN, —NH2, —N(CH3)C(O)CH3, C1-6 alkylamino, C1-6 dialkylamino, C1-6 alkoxy, C1-6 alkyl, C1-6 haloalkyl and C1-6 heteroalkyl;
• or R1A and R1B together form an oxo group or a 3 to 7 membered heterocycloalkyl comprising 1 to 2 heteroatoms selected from N, O and S and wherein said 3 to 7 membered heterocycloalkyl is optionally further substituted with 1 to 5 R1A-2 substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, —CN, —NO2, —SF5, —NH2, C1-6 alkoxy, C1-6 alkylamino, C1-6 dialkylamino, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, oxo, —S(═O)1-2—C1-6 alkyl and 3 to 7 membered heterocycloalkyl;
• R1C at each occurrence is independently selected from the group consisting of hydrogen, —F, —Cl, —Br, —I, C1-4 alkyl and C1-4 haloalkyl;
• R1D at each occurrence is independently selected from the group consisting of hydrogen, —F, —Cl, —Br, —I, —OH, C1-4 alkyl, C1-4 haloalkyl, 3 to 7 membered heterocycloalkyl;
• or R1A and R1D together form a 3-7 membered cycloalkyl or 3-7 membered heterocycloalkyl, each optionally substituted by C1-4 alkyl;
• R2 is selected from the group consisting of hydrogen, —F, —Cl, —Br, —I, —NO2, —CN, C1-6 alkyl and C1-6 haloalkyl;
• R3 is N(R3A)2, wherein each R3A is independently selected from the group consisting of hydrogen, C1-6 alkyl, and C1-6 haloalkyl;
• R4 is selected from the group consisting of C1-12 alkyl, C1-12 haloalkyl, C2-12 alkenyl, C2-12 alkynyl, —F, —Cl, —Br, —I, —(X4)0-1—CN, —(X4)0-1—NO2, —(X4)0-1—SF5, —(X4)0-1—OSF5, —(X4)0-1—OR4A, —(X4)0-1—N(R4A)2, —(X4)0-1—SR4A, —(X4)0-1—CF3, 3 to 7 membered cycloalkyl-(X4)0-1—, 3 to 7 membered heterocycloalkyl-(X4)0-1—, 5 to 6 membered heteroaryl-(X4)0-1—, phenyl-(X4)0-1—, —(X4)0-1—C(═O)N(R4A)(R4A), —(X4)0-1—C(═O)OR4A, —(X4)0-1—N(R4A)C(═O)(R4A), —(X4)0-1—N(R4A)C(═O)OR4A, —(X4)0-1—S(═O)1-2—R4A, —(X4)0-1—N(R4A)S(═O)1-2—R4A, —(X4)0-1—S(═O)1-2N(R4A)2, —(X4)0-1—C(═O)R4A, —(X4)0-1—C(═NOR4A)R4A, —(X4)0-1—N(R4A)C(═O)N(R4A)2, —(X4)0-1—OC(═O)R4A, —(X4)0-1—OP(═O)(OR4A)2, —(X4)—SC(═O)OR4A and —(X4)—SC(═O)N(R4A)2, each X4 is independently selected from the group consisting of C1-4 alkylene, C1-4 haloalkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene, R4A at each occurrence is each independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl and C1-6 heteroalkyl, or any two R4A groups attached to the same nitrogen atom are optionally combined to form a 3 to 6 membered heterocyclic ring optionally comprising 1 to 2 additional heteroatoms selected from N, O and S, and wherein a R4 group is independently optionally further substituted with 1 to 5 R4A-1 substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, —CN, —NO2, —SF5, —NH2, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkyl and C1-6 dialkylamino;
• or R3 and R4 together with the atoms to which they are attached form a 5 or 6 membered heteroaryl wherein the 5 or 6 membered heteroaryl is optionally substituted with 1 to 3 R3/4cy substituents selected from the group consisting of C1-12 alkyl, C1-12 haloalkyl, C2-12 alkenyl, C2-12 alkynyl, —F, —Cl, —Br, —I, —(X3/4)0-1—CN, —(X3/4)0-1—NO2, —(X3/4)0-1—SF5, —(X3/4)0-1—OSF5, —(X3/4)0-1—OR3/4A, —(X3/4)0-1—N(R3/4A)2, —(X3/4)0-1—SR3/4A, —(X3/4)0-1—CF3, 3 to 12 membered cycloalkyl-(X3/4)0-1-, 3 to 12 membered heterocycloalkyl-(X3/4)0-1—, 5 to 6 membered heteroaryl-(X3/4)0-1—, phenyl-(X3/4)0-1—, —(X3/4)0-1—C(═O)N(R3/4A)(R3/4A), —(X3/4)0-1—C(═O)OR3/4A, —(X3/4)0-1—N(R3/4A)C(═O)(R3/4A), —(X3/4)0-1—N(R3/4A)C(═O)OR3/4A, —(X3/4)0-1—S(═O)1-2—R3/4A, —(X3/4)0-1—N(R3/4A)S(═O)1-2—R3/4A, —(X3/4)0-1—S(═O)1-2N(R3/4A)2, —(X3/4)0-1—C(═O)R3/4A, —(X3/4)0-1—C(═NOR3/4A)R3/4A, —(X3/4)0-1—N(R3/4A)C(═O)N(R3/4A)2 and —(X3/4)0-1—OC(═O)R3/4A, —(X3/4)0-1—OP(═O)(OR3/4A)2, —(X3/4)—SC(═O)OR3/4A and (X3/4)—SC(═O)N(R3/4A)2, each X3/4 is independently selected from the group consisting of C1-4 alkylene, C1-4 haloalkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene, R3/4A at each occurrence is each independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl and C1-6 heteroalkyl, or any two R3/4A groups attached to the same nitrogen atom are optionally combined to form a 3 to 6 membered heterocyclic ring optionally comprising 1 to 2 additional heteroatom selected from N, O and S, and wherein a R3/4cy substituent at each occurrence is independently optionally further substituted with 1 to 5 R3/4cy-1 substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, —CN, —NO2, —SF5, —NH2, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkyl and C1-6 dialkylamino;
• R5 is hydrogen, —F, —Cl, —Br or —I;
• and
• R6 is selected from the group consisting of C1-12 alkyl, C1-12 haloalkyl, C1-12 heteroalkyl-(L)0-1-, C2-12 alkenyl-(L)0-1-, C2-12 alkynyl-(L)0-1-, 3 to 12 membered cycloalkyl-(L)0-1- and 3 to 12 membered heterocycloalkyl-(L)0-1-, wherein L is selected from the group consisting of C1-4 alkylene, C1-4 haloalkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene, wherein a R6 group is optionally further substituted with 1 to 5 R6A substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —OH, —CN, —NO2, —SF5, —OSF5, —NH2, C1-6 alkyl, C1-6 haloalkyl, 3 to 5 membered cycloalkyl, 3 to 5 membered heterocycloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino and C1-6 dialkylamino.