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US 2015/0175552 A1Published application
Stabilized multi-functional antioxidant compounds and methods of use
AssigneeXPD Holdings, LLC
InventorsMarc Bailie, Steven K. Duddy, Jim Herman
Life of this patent
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Abstract
Disclosed are novel stable compounds having anti-oxidant properties and methods of using the compounds for the treatment of diseases or injuries associated with oxidative stress.
Claims36
A compound of Formula I or Formula II:
- or a pharmaceutically acceptable salt thereof wherein:
- R is H, optionally substituted alkyl, or optionally substituted alkoxy;
- R1 and R2 are each independently H, alkyl, or —C(═O)R3;
- R3 is optionally substituted alkyl or optionally substituted alkoxy;
- L is —(CH2)m—;
- L1 is —CH(R5)— or —C(═O)—;
- L2 is —O— or —NH—;
- R4 is H or optionally substituted alkyl;
- R5 is H, —C(O)OH, or —C(═O)L2 R7;
- R6 is H, —(CH2)nC(═O)R8;
- R7 is H, alkyl, or —(CH2)pC(═O)OH;
- R8 is —OH, —CH3, —CH2C(═O)OH, or —(CH2)w—CH(NH2)—C(═O)OH;
- R9 is H, alkyl, or —C(═O)alkyl;
- m is 1, 2, 3, or 4;
- and
- n, p, and w, are each independently 0, 1, 2, 3, or 4.
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Dependencies are inferred from the claim text.