Fluorination of aryl compounds
AssigneeThe Regents of the University of California
InventorsJohn Hartwig, Patrick Fier
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Abstract
The invention provides compositions and methods of using the compositions in fluorinating aryl precursors containing a leaving group replaceable by fluoride ion. The compositions include a metal ion source, a fluoride ion source, and a compound, which is an aryl precursor of the aryl fluoride, and which has a leaving group replaceable by the fluoride. Exemplary methods of the invention make use of such compositions and methods to prepare an aryl fluoride compound. In an exemplary embodiment, the fluoride ion source is a source of 18F.
Claims18
A reaction mixture for fluorinating an aryl halide precursor compound having a leaving group, said reaction mixture comprising:
- (i) said aryl precursor compound, said compound optionally substituted at one or more positions with one or more substituents other than said leaving group, such that said one or more substituents are not joined to form a nitrogen-containing macrocycle with three amine moieties;
- (ii) a fluoride ion source;
- (ii) a metal ion source, wherein said metal ion source mediates the fluorinating of the aryl precursor compound, at the position of the leaving group, with fluoride derived from the fluoride ion source.
Dependencies are inferred from the claim text.