System and apparatus for increasing regularity and/or phase-locking of neural activity relating to an epileptic event
AssigneeFlint Hills Scientific, L.L.C.
InventorIvan Osorio
Life of this patent
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Abstract
A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.
Claims26
A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform a method, comprising:
- detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity,
- determining a first regularity index of said electrical activity;
- and
- applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range.
A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform a method, comprising:
- detecting a first electrical activity relating to a first epileptic activity in at least a first brain sub-region of a patient;
- detecting a second electrical activity relating to a second epileptic activity in at least a second brain sub-region of said patient;
- determining a phase-locking index between said first electrical activity and said second electrical activity;
- applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic activity, in response to said phase-locking index being inside a first range.
The non-transitive, computer-readable storage device claim of 21 wherein said promoting phase-alignment comprises at least one of:
- bringing EEG rhythms within a frequency band or bands from the first brain region and the second brain region to no more than 30 degrees out of phase between the average of said frequency band or bands from said brain regions;
- bringing extrema of frequency components of the first electrical activity and the second electrical activity to no more than 30 degrees out of phase;
- or bringing zero crossings of frequency components of the first electrical activity and the second electrical activity to no more than 30 degrees out of phase.
A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform a method, comprising:
- detecting a first electrical activity relating to a first epileptic activity in at least a first brain sub-region of a patient;
- detecting a second electrical activity relating to a second epileptic activity in at least a second brain sub-region of said patient;
- determining a phase-locking index between at least said first electrical activity and said second electrical activity;
- applying at least one first electrical stimulation to at least one neural target of said patient to modify said phase-locking index if said phase-locking index is outside a first range;
- and
- applying at least one second electrical stimulation to at least one neural target of said patient to treat said epileptic activity.
A medical device system, comprising:
- an epileptic event detection module configured to detect an epileptic event;
- at least one sensor configured to collect one or more electrical activity signals from at least one region of the brain of a patient;
- a regularization determination module configured to determine the regularity of said electrical activity,
- a neuronal regularization module configured to modify a regularity index of electrical activity in said at least one brain region of said patient;
- a phase-locking determination module configured to determine the degree of phase-locking between said first electrical activity and said second electrical activity,
- a phase-locking module configured to modify a phase-locking index between a first electrical activity in said at least one brain region and a second electrical activity in a second brain region of said patient, and
- a stimulation module configured to apply an electrical stimulation to at least one neural target of said patient based on an indication of said epileptic event.
Dependencies are inferred from the claim text.