Long term drug delivery devices with polyurethane based polymers and their manufacture

A process of manufacturing drug delivery devices made with thermoplastic polyurethanes, said process comprising:

• a) precision extrusion or injection molding step to produce a hollow tube made of thermoplastic polyurethane with two open ends with desired physical dimensions;
• b) sealing one of the open ends of the hollow tube;
• c) loading a reservoir containing a desired formulation containing an active ingredient and optionally, carriers or filling a reservoir with pre-fabricated pellets;
• d) sealing the second open end of the hollow tube;
• e) conditioning and priming of the drug delivery devices to achieve the desired delivery rates for the actives.

A process of manufacturing drug delivery devices made with thermoset polyurethanes, said process comprising:

• a) precision reaction injection molding or spin casting a hollow tube having two open ends;
• b) curing the hollow tube;
• c) sealing one end of the hollow tube;
• d) loading a reservoir containing a desired formulation containing actives and, optionally, carriers or filling a reservoir with pre-fabricated pellets;
• e) sealing the second end of the hollow tube;
• and
• f) conditioning and priming of the drug delivery devices to achieve the desired delivery rates for the actives.