US 2015/0174283 A1 · Smart, Self-Decontaminating Polymer and Method for Inhibiting The Growth Of A Bacteria and Fungus

Abstract

A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.

Claims8

Dependent claims

A material comprising:

an excipient;
a polymer mixed with said excipient;
at least one protein that is covalently linked or crosslinked to said polymer;
and
an aqueous composition, wherein said protein is in a sufficient amount to catalyze a conversion of a chemical constituent placed in contact with the material, and wherein said protein is capable of undergoing hydrolysis in response to a target analyte to release at least one or more of a disinfectant, an antimicrobial, an antioxidant, or combinations thereof from said polymer.

2 more elements

A dressing comprising:

a single layer comprising a first side and a second side, wherein said first side is facing an opposite direction relative to said second side, and wherein said first side and said second side are disposed in juxtaposition to each other forming said layer having a desired height, length and width;
a polymer disposed on at least said first side of said layer or within said layer, and optionally including wherein said polymer is disposed on said second side of said layer or within said layer;
at least one protein that is covalently linked or crosslinked to said polymer, and wherein said protein is disposed on at least said first side of said layer or within said layer, and optionally including wherein said protein is disposed on said second side of said layer or within said layer;
and
an aqueous composition disposed within said layer, wherein said protein is in a sufficient amount to catalyze a conversion of a chemical constituent placed in contact with said layer, and wherein said protein is capable of undergoing hydrolysis in response to a target analyte to release at least one or more of a disinfectant, an antimicrobial, an antioxidant, or combinations thereof from said polymer.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/635,294Filed 2 Mar 2015

Priority

15 Jun 2012

Published

25 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61L 15/38
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons: containing enzymes
A61F 13/00059
Accessories for dressings: provided with visual effects, e.g. printed or colored
A61F 13/00063
Accessories for dressings: comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
A61K 38/443
Oxidoreductases: acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase

Family

Application61/660,065Us provisional application · filed 15 Jun 2012

Application13/915,839Division · filed 12 Jun 2013

Application14/635,294Division

US 2013/0344130 A1Published application

US 9,452,237 B2Related patent

US 2015/0174283 A1This patent

From the US filing history. Foreign family members aren’t listed.

Smart, Self-Decontaminating Polymer and Method for Inhibiting The Growth Of A Bacteria and Fungus

Life of this patent

Smart, Self-Decontaminating Polymer and Method for Inhibiting The Growth Of A Bacteria and Fungus

Life of this patent

Abstract

Claims8