Back to results
US 2015/0174264 A1Published application
Oligomer-Antihistamine Conjugates
AssigneeNektar Therapeutics
InventorsJennifer Riggs-Sauthier, Wen Zhang, Tacey X. Viegas, Michael D. Bentley
Life of this patent
Estimating the term…
Abstract
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
Claims22
A compound having the following structure:
- wherein:
- (a) is either zero or one;
- Z is selected from the group consisting of N, CH and C(CH3);
- either (i) Ar1 is an aromatic-containing moiety, and Ar2 is an aromatic-containing moiety, or
- is combined to form an aromatic-containing moiety;
- X is a spacer moiety;
- and
- POLY is a water-soluble, non-peptidic oligomer.
5 more elements
A compound having the following structure:
- wherein:
- (a) is either zero or one;
- Z is selected from the group consisting of N, CH and C(CH3);
- either (i) Ar1 is an aromatic-containing moiety, and Ar2 is an aromatic-containing moiety, or
- is combined to form an aromatic-containing moiety;
- X is a spacer moiety;
- and
- POLY is a water-soluble, non-peptidic oligomer.
5 more elements
A compound having the following structure:
- wherein:
- (a) is either zero or one;
- Z is selected from the group consisting of N, CH and C(CH3);
- either (i) Ar1 is an aromatic-containing moiety, and Ar2 is an aromatic-containing moiety, or
- is combined to form an aromatic-containing moiety;
- and
- POLY is a water-soluble, non-peptidic oligomer.
4 more elements
Dependencies are inferred from the claim text.