Gluten-related disorders
AssigneeH.J. Heinz Company
InventorsFrancesca Romana Fasano, Andrea Luigi Budelli
Life of this patent
Estimating the term…
Abstract
The present invention features compositions and methods for treating gluten-related disorders. We describe compositions comprising one or more metabolites produced by Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778 that reduce cellular entry of gliadin peptides. The compositions may include a physiologically acceptable carrier, for example, a food product or a pharmaceutical carrier. The compositions can be administered to a subject having a gluten-related disorder, for example, celiac disease or gluten sensitivity.
Claims33
A composition comprising a metabolite produced by Lactobacillus paracaseiCBA L74, International Depository Accession Number LMG P-24778, wherein the metabolite reduces a symptom of gliadin peptide toxicity in a subject having a gluten-related disorder.
A method of treating a subject having a gluten-related disorder, the method comprising:
- a) identifying a subject in need of treatment;
- b) administering an effective amount of a composition comprising a metabolite produced by Lactobacillus paracaseiCBA L74, International Depository Accession Number LMG P-24778, wherein the metabolite reduces a symptom of gliadin peptide toxicity.
Use of a metabolite produced by Lactobacillus paracaseiCBA L74, International Depository Accession Number LMG P-24778, for the preparation of a composition for reducing a symptom of gliadin peptide toxicity in a subject having a gluten-related disorder.
A kit comprising a measured amount of composition comprising a metabolite produced by Lactobacillus paracaseiCBA L74, International Depository Accession Number LMG P-24778, wherein the metabolite reduces a symptom of gliadin peptide toxicity, and one or more items selected from the group consisting of packaging material, a package insert comprising instructions for use, a sterile fluid, a syringe and a strerile container.
Dependencies are inferred from the claim text.