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US 2015/0174191 A1Published application
Pharmaceutical composition for treating hyperproliferative diseases
AssigneeOOO “MetaMax”
InventorVladimir Konstantinovich Bojenko
Life of this patent
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Abstract
The present invention relates to the field of biotechnology and medicine, in particular to a pharmaceutical composition having an antiproliferative activity and comprising an chimeric peptide and to a method of treating oncologic diseases, which includes introducing the chimerical peptide into a mammal requiring such treatment. The objective of the of invention is the development of a preparation that effectively penetrates the target cells and has a high cytostatic and cytotoxic activity.
Claims19
1-13. (canceled)
A pharmaceutical composition comprising:
- (a) a pharmaceutically acceptable carrier, and (b) a chimeric peptide comprising a functional sequence of protein inhibitor of cyclin kinase p16INK4a (SEQ ID NO:
- 1) or p21/CIP/KIP (SEQ ID NO:
- 6) and a transport sequence, wherein the functional sequence and the transport sequence are linked by a group X, wherein X represents an amino acid sequence comprising from 1 to 50 amino acid residues, and wherein the chimeric peptide has the amino acid sequence of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 7, or SEQ ID NO:
- 8.
4 more elements
Dependencies are inferred from the claim text.