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US 2015/0174183 A1Published application
Methods and pomegranate extract composition for treating diabetes related atherosclerotic complications in humans
AssigneePOM Wonderful, LLC
InventorMichael AVIRAM
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Abstract
One or more embodiments of the invention are directed to methods of using pomegranate extracts for treating diabetes related atherosclerotic complications in humans. The methods comprise the step of administering to the patients a composition comprising a therapeutically effective amount of an extract from pomegranate.
Claims18
A composition for treating diabetes-related symptoms comprising:
- a therapeutically effective amount of a pomegranate composition, wherein said therapeutically effective amount of said pomegranate composition comprises an amount sufficient to result in anti-atherogenic effects with a significant reduction in oxidative stress in a patient's serum and monocytes-macrophages, as well as in macrophage uptake of Ox-LDL to said patient to affect at least one diabetes-related symptom, wherein said pomegranate composition is obtained from a process comprising:
- crushing, squeezing, and enzymatically treating whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component;
- separating the juice component from the insoluble by-product component;
- resuspending the insoluble by-product component in an aqueous medium;
- crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- separating the soluble portion from the insoluble portion;
- and
- combining the soluble portion with the juice component to produce the pomegranate composition.
5 more elements
A composition for treating diabetes-related symptoms of a diabetic patient comprising:
- a therapeutically effective amount of a pomegranate composition to reduce oxidative stress in a diabetic patient, and wherein said therapeutically effective amount of said pomegranate composition comprises a quantity sufficient to result in anti-atherogenic effects with a significant reduction in oxidative stress in said patient's serum and monocytes-macrophages, as well as in macrophage uptake of Ox-LDL, wherein said pomegranate composition is obtained from a process comprising:
- crushing, squeezing, and enzymatically treating whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component;
- separating the juice component from the insoluble by-product component;
- resuspending the insoluble by-product component in an aqueous medium;
- crushing, squeezing, and mixing the resuspended by-product component to yield a soluble portion and an insoluble portion;
- separating the soluble portion from the insoluble portion;
- and
- combining the soluble portion with the juice component to produce the pomegranate composition, wherein said pomegranate composition is diluted 1:5 (v/v) with water.
5 more elements
Dependencies are inferred from the claim text.