Skin and hair regeneration using polysaccharide-based hydrogels
AssigneeThe Johns Hopkins University
InventorsSharon Gerecht, Xianjie Zhang, John W. Harmon, Guoming Sun
Life of this patent
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Abstract
Methods for promoting skin regeneration, promoting hair follicle regeneration, and reducing scarring by topically administering polysaccharide-based hydrogel compositions to injured skin are presented.
Claims21
A method of treating a subject with an area of injury damaging the skin comprising topically administering to the subject a hydrogel on at least a portion of the injured area, the hydrogel comprising a crosslinked composition comprising:
- at least about 80% of a polysaccharide with at least one monomer having at least one substituted hydroxyl group, wherein the substituted hydroxyl group has the formula (III):
- —O1—C(O)NR7—CH2CH═CH2 (III)
- wherein O1 is the oxygen atom of said substituted hydroxyl group, R7 is hydrogen or C1-C4 alkyl;
- and up to about 20% of a second crosslinkable molecule, thereby promoting skin regeneration, promoting hair follicle regeneration or reducing scarring in the injured area.
A method of promoting hair follicle regeneration comprising topically administering to a subject with an area of injury damaging the skin, a hydrogel on the injured area, the hydrogel comprising a crosslinked composition comprising:
- at least about 80% of a polysaccharide with at least one monomer having at least one substituted hydroxyl group, wherein the substituted hydroxyl group has the formula (III):
- —O1—C(O)NR7—CH2CH═CH2 (III)
- wherein O1 is the oxygen atom of said substituted hydroxyl group, R7 is hydrogen or C1-C4 alkyl;
- and up to about 20% of a second crosslinkable molecule, thereby promoting hair follicle regeneration.
A method of reducing scarring comprising topically administering to a subject with an area of injury damaging the skin, a hydrogel on the injured area, the hydrogel comprising a crosslinked composition comprising:
- at least about 80% of a polysaccharide with at least one monomer having at least one substituted hydroxyl group, wherein the substituted hydroxyl group has the formula (III):
- —O1—C(O)NR7—CH2CH═CH2 (III)
- wherein O1 is the oxygen atom of said substituted hydroxyl group, R7 is hydrogen or C1-C4 alkyl;
- and up to about 20% of a second crosslinkable molecule, thereby reducing scarring.
(canceled)
Dependencies are inferred from the claim text.