Chitosan hydrogel for repairing nerve tissue

A method of neuron regenerating and/or repairing of the nervous system, and/or grafting of neurons or precursors of neural cells and/or treatment of neurodegenerative diseases and/or treatment of ischemic bonds and/or treatment of paralyses, the method comprising:

• administering to a mammal in need thereof an effective amount of chitosan hydrogel microparticles;
• wherein said microparticles have a median size d50, obtained from a number distribution, of from 1 to 500 μm;
• wherein said chitosan has a degree of acetylation of less than or equal to 20%;
• and
• wherein the concentration of chitosan in the hydrogel is from 0.25 to 5% by weight, based on the total weight of the hydrogel.

An implant comprising an aqueous suspension of microparticles

• wherein said microparticles have a median size d50, obtained from a number distribution, of from 1 to 500 μm;
• wherein said chitosan has a degree of acetylation of less than or equal to 20%;
• and
• wherein the concentration of chitosan in the hydrogel is from 0.25 to 5% by weight, based on the total weight of the hydrogel.
• wherein said microparticles are mixed with a member selected from the group consisting of Schwann cells, stem cells, trophic factors, and a combination thereof.