Treating ewing's sarcoma and ews-fli1 related disorders
AssigneeStar Biotechnology, LLC
InventorsRamani Aiyer, James E. O'Dorisio
Life of this patent
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Abstract
The field relates to compositions and methods for treating Ewing's Sarcoma and other disorders related to EWS-FLI1.
Claims17
A pharmaceutical composition, comprising the compound of Formula I:
- or a pharmaceutically acceptable salt thereof in an amount effective to treat Ewing's Sarcoma in a subject in need thereof, and further comprising an organic solvent, an organic co-solvent and a lipid in a pharmaceutically acceptable aqueous liquid unit dosage form.
A method for treatment or prophylaxis of Ewing's sarcoma in a subject in need thereof, comprising administering to the subject at least once a day for at least 1.5 days, the compound of Formula I or a pharmaceutically acceptable salt thereof.
A method for treatment or prophylaxis of Ewing's sarcoma in a subject in need thereof, comprising administering to the subject the compound of Formula I or a pharmaceutically acceptable salt thereof such that plasma levels of at least 1 micromolar (μM) of the compound of Formula I are sustained in the subject's plasma for at least 36 hours.
Dependencies are inferred from the claim text.