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US 2015/0174081 A1Published application
Liquid pharmaceutical composition comprising nitisinone
AssigneeSwedish Orphan Biovitrum International AB
InventorsLennart SVENSSON, Hans SIDEN
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Abstract
The invention concerns a liquid pharmaceutical formulation suitable for oral administration, comprising a suspension of an effective amount of micronized 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (nitisinone); and citric acid buffer having a pH in the range of 2.5 to 3.5. The formulation is useful in the treatment of disorders and diseases in which inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD) is desirable, e.g. in hereditary tyrosinaemia type I.
Claims19
A liquid pharmaceutical formulation suitable for oral administration, comprising
- (a) a suspension of an effective amount of micronized 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (nitisinone);
- and
- (b) citric acid buffer having a pH in the range of 2.5 to 3.5, or having a pH of 3.0.
Dependencies are inferred from the claim text.