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US 2015/0174078 A1Published application
Sustained Release Formulations of Lorazepam
AssigneeEdgemont Pharmaceuticals LLC
InventorsDouglas A. Saltel, Michael Vachon
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition for delivering lorazepam in a prolonged fashion is achieved with prolonged release lorazepam pharmaceutical beads. The composition typically contains sustained release lorazepam beads and delayed sustained release lorazepam beads. The composition can provide once daily dosing that maintains 24 hour therapeutic effect under steady state conditions.
Claims21
1-20. (canceled)
A pharmaceutical composition, comprising:
- (i) lorazepam sustained release beads, which beads comprise lorazepam dispersed in a polymer matrix;
- and
- (ii) lorazepam delayed sustained release beads, which delayed beads comprise a core having lorazepam dispersed in a polymer matrix and an enteric coating surrounding said core;
- wherein said lorazepam sustained release beads and said lorazepam delayed sustained release beads are present in a ratio range of 1:0.7-1.3, respectively, at least 90% of the total amount of lorazepam in said composition is contained in the combination of said lorazepam sustained release beads and said lorazepam delayed sustained release beads, and the total amount of lorazepam contained in said composition is 0.5 to 10 mg.
1 more element
A method for treating anxiety related disorders, which comprises administering once a day to a patient in need thereof a pharmaceutical composition according to claim 1.
Dependencies are inferred from the claim text.