Apparatus, Composition, and Related Methods for Transdermal Delivery of Active Ingredients
AssigneeCure IP Holdings, LLC
InventorsRobert S. Davidson, Eric Allen, Jose Bernado, Edward Maliski
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Abstract
In accordance with a composition aspect of the invention, a composition for applying to skin comprises one or more pharmaceutically active ingredients contained in a plurality of hydrophobic carriers dispersed throughout a hydrogel, a skin permeation enhancer for enhancing the permeation of the active ingredients into skin, and an emulsifier. The amount of hydrogel is sufficient to allow the hydrogel to dry to as a substantially continuous film over and in contact with the skin to which it is applied. Related method and apparatus aspects are also described.
Claims84
A composition for applying to skin, the composition comprising:
- one or more pharmaceutically active ingredients contained in a plurality of hydrophobic carriers dispersed throughout a hydrogel;
- a skin permeation enhancer for enhancing the permeation of the active ingredients into skin;
- and
- an emulsifier;
- wherein the amount of hydrogel is sufficient to allow the hydrogel to dry to as a substantially continuous film over and in contact with the skin to which it is applied.
A composition comprising 3.7%-4.1% w/w pectin, 3%-7% w/w menthol, 1%-3% w/w glycerin, and 1%-3% w/w grapeseed oil, each combined with one or more pharmaceutically active ingredients in an aqueous medium.
A method of making a topical composition, the method comprising:
- mixing grapeseed oil and glycerin with an aqueous solution heated to a temperature of approximately 70° C. to approximately 90° C.;
- adding one or more pharmaceutically active ingredients, menthol, and pectin to the mixture to form a blend;
- and
- agitating the blend until it becomes homogeneous;
- wherein the blend comprises 3.7%-4.1% w/w pectin, 3%-7% w/w menthol, 1%-3% w/w glycerin, and 1%-3% w/w grapeseed oil.
A composition comprising 3.7%-4.1% w/w pectin, 3%-7% w/w menthol, 1%-3% w/w glycerin, and 2%-4% w/w phosphatidyl serine, each combined with one or more pharmaceutically active ingredients in an aqueous medium.
A method of making a topical composition, the method comprising:
- electrically charging carboxylated phospholipids by blending the carboxylated phospholipids with a hydroxide salt in an aqueous solution heated to a temperature of approximately 70° C. to approximately 90° C. to form a charged phospholipid solution;
- agitating the charged phospholipid solution with sufficient agitation intensity to open any liposomes therein;
- adding one or more pharmaceutically active ingredients to the charged phospholipid solution to form a blend;
- agitating the blend with sufficient agitation intensity to open any liposomes in the blend;
- reducing the agitation intensity and waiting for a time sufficient to allow liposomes to encapsulate the one or more pharmaceutically active ingredients to form a liposome solution;
- blending an emulsifier with the liposome solution;
- adding a skin permeation enhancer to the liposome solution with agitation, the skin permeation enhancer being located external to the liposomes to form an enhanced liposome solution;
- and
- adding pectin to the enhanced liposome solution to form a topical composition.
A transdermal formulation for topical administration, comprising:
- at least one active ingredient, wherein the at least one active ingredient is contained in a plurality of hydrophobic carriers dispersed in an aqueous medium containing a hydrocolloid, wherein the amount of aqueous medium is sufficient to create a substantially continuous film over the applied area;
- a skin permeation enhancer for enhancing the permeation of the active ingredient(s) into the skin;
- a vasodilator;
- and
- an emulsifier.
Dependencies are inferred from the claim text.