Multi-layer capsule and manufacture method thereof
AssigneeOrient Pharma Co., Ltd.
InventorsIkuo Goto, Chin-Chih Chiang, Yen-Fei Chen
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Abstract
The present invention provides multi-layer capsules and manufacture methods thereof Different materials are added in sequence into a capsule to form a multi-layer capsule without diffusion and/or interaction between layers.
Claims26
A multi-layer capsule comprising at least two layers of homogeneous materials and at least one barrier layer where each layer of homogenous material comprises the same or different biopharmaceutical ingredient, and wherein each layer of homogeneous material has the same or different form of liquation as the other layers.
A multi-layer capsule comprising:
- a body comprising at least one opening and an internal space;
- at least one cover body to mount or dismount over the at least one opening of the body;
- a barrier layer disposed in the internal space of the body to separate the first compartment and the second compartment wherein the barrier layer is solid at room temperature and semi-solid or liquid at a temperature higher than 35° C.
A method of manufacturing a multi-layer capsule, the method comprising
- providing a capsule comprising a body, and at least one cover body wherein the body has an internal space and at least one opening;
- adding a first homogeneous material, a second homogeneous material, and a barrier layer to the internal space of the body wherein the barrier layer is added before or after the first homogeneous material;
- and
- mounting the at least one cover body over the at least one opening of the body, wherein the first and second homogeneous material is separated by the barrier layer.
Dependencies are inferred from the claim text.