Drug refill applicator system and method of use

Apparatus for refilling a reservoir, the apparatus comprising:

• a plurality of reservoirs;
• a plurality of reservoir fluid channels each associated with one of the reservoirs;
• an outlet fluid channel fluidically connected to the reservoir fluid channels;
• a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel;
• at least one sensor for monitoring pressure in the reservoir fluid channels and the outlet fluid channel;
• at least one actuation mechanism;
• a needle having a lumen in fluid communication with the outlet fluid channel, the needle being configured for insertion into a drug-delivery port of an implantable medical device;
• and
• a controller for actuating at least one said pump and various ones of the valves in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.