Method Of Production Of New Polymeric Material

Method for preparing a material as interpenetrating polymer network (IPN) associating a gel with a co-network of functionalized synthetic polymer crosslinked with a functionalized protein, comprising the steps of:

• i) preparing a first mixture by introducing into a buffer
• a. a gel forming solution or a gel forming precursor solution,
• b. a synthetic polymer selected in the group consisting of polyvinyl alcohol (PVA), polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL), poly(N-vinylpyrolidone), poly(2-hydroxy ethyl methacrylate) (PHEMA), polyethyleneoxide (PEO), and derivatives thereof, wherein the polymer is functionalized with grafted chemical groups X, X being selected in the group consisting of acrylate, methacrylate, vinyl, allyl and styrene and their derivatives,
• c. a protein functionalized with grafted chemical groups X, wherein X is has the same meaning then in b)
• d. a polymerization initiator,
• ii) preparing a second reaction mixture by optionally addition a gelification activator of the formation of the gel to the first mixture prepared in i),
• iii) incubating the reaction mixture obtained in i) or in ii) at a temperature and during a time sufficient to allow formation of the gel, and
• iv) performing a polymerizing and crosslinking of the functionalized synthetic polymer with the functionalized protein.