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US 2015/0166477 A1Published application
Compounds for the treatment of mtor pathway related diseases
AssigneesPitney Pharmaceuticals Pty Limited, NewSouth Innovations Pty Limited
InventorsMohammad Hossein Pourgholami, David L. Morris, Roger Aston
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Abstract
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of mTOR pathway related diseases.
Claims68
A compound of formula (I):
- or a metabolite, pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of one or more mTOR pathway related diseases, wherein,
- R1, R2 and R3 and R5 are each independently selected from H, alkyl, halogen, —CF3 or —CN;
- R4 and R6 are each independently selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2CF3, —SOCF3 or —SCF3;
- X is heteroatom, N(alkyl) or NH;
- and
- n is 1 to 20.
3 more elements
A method for the treatment of one or more mTOR pathway related diseases, the method comprising administering a therapeutically effective amount of a compound of formula (I):
- or a metabolite, pharmaceutically acceptable salt, solvate or prodrug thereof, to a patient in need thereof, wherein
- R1, R2 and R3 and R5 are each independently selected from H, alkyl, halogen, —CF3 or —CN;
- R4 and R6 are each independently selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2CF3, —SOCF3 or —SCF3;
- X is heteroatom, N(alkyl) or NH;
- and
- n is 1 to 20.
3 more elements
Use of a compound of formula (I):
- or a metabolite, pharmaceutically acceptable salt, solvate or prodrug thereof, for the manufacture of a medicament for the treatment of one or more mTOR pathway related diseases, wherein
- R1, R2 and R3 and R5 are each independently selected from H, alkyl, halogen, —CF3 or —CN;
- R4 and R8 are each independently selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2CF3, —SOCF3 or —SCF3;
- X is heteroatom, N(alkyl) or NH;
- and
- n is 1 to 20.
3 more elements
Dependencies are inferred from the claim text.