US 2015/0166468 A1Published application

Process for Preparing 5-biphenyl-4-amino-2-methyl Pentanoic Acid

AssigneeNovartis AG

InventorsDavid Hook, Thomas Ruch, Bernard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar Murlidhar Waykole

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Abstract

The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

Claims20

Dependent claims

A process for producing a compound according to formula (18) or a salt thereof

comprising the steps
a) providing a compound according to formula (1), or tautomer, or salt thereof,
b) methylating the compound according to formula (1), or tautomer, or salt thereof, to obtain a compound according to formula (2), or tautomer, or salt thereof,
c) reacting the compound according to formula (2), or tautomer, or salt thereof, with a ring opening agent to obtain a compound according to formula (3) or a salt thereof
d) reacting a compound according to formula (3) or a salt thereof to obtain a compound according to formula (18) or a salt thereof,
wherein in the above formulae R1 and R2 are independently, of each other, hydrogen or a nitrogen protecting group and R3 is hydrogen or alkyl.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/627,542Filed 20 Feb 2015
Priority: EP 07100451.912 Jan 2007
Published: 18 Jun 2015
Term ends: Not estimatedThe source records don’t support an estimate.

Classification38 codes

C07C 231/02
Preparation of carboxylic acid amides: from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 9/04
Drugs for disorders of the cardiovascular system: inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/08
Drugs for disorders of the cardiovascular system: vasodilators for multiple indications

Family

Application12/522,767Division · filed 10 Jul 2009
Application13/333,437Division · filed 21 Dec 2011
Application14/224,700Division · filed 25 Mar 2014
Application14/627,542Division
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From the US filing history. Foreign family members aren’t listed.