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US 2015/0158832 A1Published application
Compounds and methods of treating cancer
AssigneeThe Regents of the University of California
InventorsRichard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
Life of this patent
Estimating the term…
Abstract
Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
Claims25
A compound having the formula:
- wherein;
- L1 and L2 are independently a bond or —NH—C(NH)—;
- R1 is —NR1AR1B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R1A and R1B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl;
- R2 is —NR2AR2B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R2A and R2B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl;
- R1A, R1B, R2A, and R2B are independently hydrogen, —OR4, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3 is hydrogen or unsubstituted C1-C5 alkyl;
- and
- R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- wherein if L1 and L2 are a bond and R1 is 4′-Me piperidine, R2 is not —NH2;
- wherein if L1 and L2 are a bond and R1 is —C(CH3)(CH3), R2 is not —NH2;
- wherein if L1 and L2 are a bond and R1 is phenyl, R2 is not —NH2;
- wherein if L1 and L2 are a bond and R1A and R1B are both hydrogen, then R2A and R2B are not both methyl;
- wherein if L1 and L2 are a bond and R1 is 2′- or 3′-pyridinyl, R2 is not NH2;
- and
- wherein L1 and L2 are a bond and R1A and R1B are both methyl, R2 is not morpholino.
12 more elements
-11. (canceled)
(canceled)
-34. (canceled)
-53. (canceled)
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound having formula:
- wherein;
- L1 and L2 are independently a bond or —NH—C(NH)—;
- R1 is —NR1AR1B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R1A and R1B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl;
- R2 is —NR2AR2B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R2A and R2B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl,
- R1A, R1B, R2A, and R2B are independently hydrogen, —OR4, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3 is hydrogen or unsubstituted C1-C5 alkyl;
- and
- R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
5 more elements
A method of treating cancer in a subject in need thereof, said method comprising administering a therapeutically effective amount a compound having formula:
- wherein;
- L1 and L2 are independently a bond or —NH—C(NH)—;
- R1 is —NR1AR1B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R1A and R1B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl;
- R2 is —NR2AR2B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R2A and R2B are optionally joined together to form a substituted or unsubstituted heterocycloalkyl,
- R1A, R1B, R2A, and R2B are independently hydrogen, —OR4, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3 is hydrogen or unsubstituted C1-C5 alkyl;
- and
- R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
5 more elements
-69. (canceled)
Dependencies are inferred from the claim text.