Substituted androst-4-ene diones
AssigneesEmory University, Research Foundation of the State of New York, Hauptman-Woodward Medical Research Institute, Inc.
InventorsHuw Davies, Debashis Ghosh, Daniel Morton
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Abstract
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.
Claims8
A method of treating a hormone-related disorders comprising administering a compound of Formula C
- or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof, wherein
- ----- represents a bond present as a double bond and
- R2 is selected from the group consisting of an alkenyl group and an alkynyl group, either of which may be optionally substituted, to a subject in need thereof.
Dependencies are inferred from the claim text.