# US 2015/0147804 A1 · Biochemical analysis cartridge having improved operability > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2015/0147804 A1 - Document ID: US20150147804A1 - Status: Published application - Kind: A1 - Application number: 14/608,564 - Filed: 2015-01-29 - Published: 2015-05-28 - Earliest claimed: 2012-07-31 - Assignees: I-Sens, Inc. - Applicants: I-Sens, Inc. - Inventors: Geun Sig CHA; Hakhyun NAM; Dongxuan SHEN; Joo Young CHO; Jihoon KIM - Web page: https://patentgrep.com/patent/US20150147804A1 ## CPC - G01N 33/726: {Devices} - B01L 3/502: {with fluid transport, e.g. in multi-compartment structures} - G01N 33/54366: {Apparatus specially adapted for solid-phase testing} - G01N 33/723: {Glycosylated haemoglobin} - B01L 2300/045: whereby the whole cover is slidable - B01L 2300/047: Additional chamber, reservoir - B01L 2300/0672: Integrated piercing tool - B01L 2300/0816: Cards, e.g. flat sample carriers usually with flow in two horizontal directions - B01L 2300/0835: Ampoules - B01L 2300/0867: Multiple inlets and one sample wells, e.g. mixing, dilution - B01L 2400/0409: centrifugal forces - B01L 2400/0457: passive flow or gravitation - B01L 2400/0683: mechanically breaking a wall or membrane within a channel or chamber - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ## Abstract The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability. ## Claims ### Claim 1 A biochemical analysis cartridge comprising an insertion-type sample cartridge for supplying a sample and a reaction cartridge receiving the insertion-type sample cartridge, wherein the reaction cartridge includes: a receiving unit into which the insertion-type sample cartridge is inserted to be received; a chamber for storing a reaction solution, provided inside the receiving unit with an opening at one end, including a covertape attached to the opening to prevent the discharge of the stored reaction solution, and provided such that the opening to which the covertape is attached faces the inside of the reaction cartridge; a covertape breaking unit provided to oppose the covertape of the chamber for storing the reaction solution and provided to be distant from the covertape; a chamber moving frame fixing the chamber for storing the reaction solution and including a moving path through which the chamber for storing the reaction solution moves toward the covertape breaking unit; and a mixing unit receiving the discharged reaction solution when the covertape is removed and mixing the reaction solution and a discharged bio-sample by contacting the reaction solution with a sample inlet of the insertion-type sample cartridge to form a mixed solution; a sample introduction unit where the sample is fixed to react with the mixed solution of the mixing unit; a measurement unit optically measuring a result of the reaction; and a flow path through which the mixing unit, the sample introduction unit, and the measurement unit are connected; and the insertion-type sample cartridge includes: a capillary-type sample injection unit for collecting and storing a liquid phase bio-sample which has a sample inlet for supplying the stored bio-sample to the reaction cartridge; and a protrusion which contacts the chamber for storing a reaction solution of the reaction cartridge to move the chamber for storing a reaction solution to the covertape breaking unit when the insertion-type sample cartridge is inserted into the receiving unit. ### Claim 2 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the chamber for storing a reaction solution moves toward the covertape breaking unit to break the covertape at the same time when the insertion-type sample cartridge is inserted into the reaction cartridge. ### Claim 3 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the reaction cartridge includes a plurality of sample introduction units. ### Claim 4 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the reaction is an enzyme reaction between a substrate in the mixed solution and an enzyme in the sample, or an antigen-antibody reaction between an antigen in the mixed solution and an antibody in the sample. ### Claim 5 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the mixed solution of the bio-sample and a chemical reagent is moved along the flow path to the measurement unit or the sample introduction unit by gravity and centrifugal force caused by rotation of the entire biochemical analysis cartridge. ### Claim 6 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the reaction cartridge of the biochemical analysis cartridge further includes a waste liquid treatment unit for treating the mixed solution of the bio-sample, the reaction solution, and the chemical reagent after measurement. ### Claim 7 (depends on 6) The biochemical analysis cartridge as set forth in claim 6, wherein the reaction cartridge of the biochemical analysis cartridge further includes an air outlet for smooth movement and collection of the waste liquid. ### Claim 8 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the biochemical analysis cartridge is a biochemical analysis cartridge for blood assay. ### Claim 9 (depends on 1) The biochemical analysis cartridge as set forth in claim 1, wherein the biochemical analysis cartridge is a biochemical analysis cartridge for glycated hemoglobin quantitative assay.