# US 2015/0147747 A1 · Composition comprising of a conducting polymer for detecting, capturing, releasing, and collecting cell > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2015/0147747 A1 - Document ID: US20150147747A1 - Status: Published application - Kind: A1 - Application number: 14/141,366 - Filed: 2013-12-26 - Published: 2015-05-28 - Earliest claimed: 2013-11-25 - Assignees: National Cancer Center - Applicants: National Cancer Center - Inventors: Young-Nam Cho - Web page: https://patentgrep.com/patent/US20150147747A1 ## CPC - G01N 33/5308: {for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites} - G01N 33/5438: {Electrodes} - G01N 33/575: for cancer - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract The present invention relates to a composition in which a conducting polymer is doped with a dopant, and a diagnostic apparatus, and more particularly, to a composition which is used to diagnose a disease and detect a biomaterial and also used for qualification and diagnosis by effectively and non-destructively collecting a captured biomaterial. Further, the composition can maximize capturing efficiency by being attached to a surface of a nano-structured scaffold and can be used as an ultrahigh-sensitive sensor using various linked bodies. ## Claims ### Claim 1 A method for detecting a pathogenic material in a sample, comprising contacting the sample with a doped composition comprising a dopant and a conducting polymer. ### Claim 2 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the dopant is doped into the conducting polymer. ### Claim 3 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the dopant comprises one or more dopant selected from the group consisting of biotin, streptavidin, and antibody. ### Claim 4 (depends on 3) The method for detecting a pathogenic material of claim 3, wherein the antibody is an anti-EpCAM (Epithelial Cell Adhesion Molecule), an anti-PSA (Prostate-Specific Antigen: KLK3 (Kallikrein)), an anti-PSMA (Prostate-Specific Membrane Antigen), an anti-PSCA (Prostate Stem Cell Antigen), an anti-STEAP (Six Transmembrane Epithelial Antigen of the Prostate), an anti-hTERT (human TElomerase Reverse Transcriptase), an anti-WT1 (Wilms tumor 1), an anti-MAGE (Melanoma Antigen Family A)-A2, an anti-5T4(oncofetal antigen 5T4), an anti-MAGE-A3, an anti-MUC1 (Mucin 1, cell surface associated), an anti-Her-2/neu (human epidermal growth factor receptor 2), an anti-CEA (Carcinoembryonic Antigen), an anti-survivin, an anti-MAGE-C1, or an anti-MAGE-C2. ### Claim 5 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the doped composition comprises a form in which an antibody is bonded to a conducting polymer or a form in which an antibody is bonded to a linked body comprising biotin and streptavidin repeatedly linked in order. ### Claim 6 (depends on 5) The method for detecting a pathogenic material of claim 5, wherein the linked body repeatedly linked in order comprises 1 to 50 singly linked bodies of biotin and streptavidin repeatedly linked. ### Claim 7 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the pathogenic material is an antibody, a blood corpuscle, DNA, RNA, a protein, an enzyme, a bacteria, a virus, or a cell. ### Claim 8 (depends on 7) The method for detecting a pathogenic material of claim 7, wherein the cell is a cancer cell. ### Claim 9 (depends on 8) The method for detecting a pathogenic material of claim 8, wherein the cancer cell is a liver cancer cell, a colorectal cancer cell, a rectal cancer cell, an endometrial cancer cell, an ovarian cancer cell, a renal-pelvis cancer cell, a pancreas cancer cell, a small intestine cancer cell, a hepatobiliary pancreas cancer cell, a stomach cancer cell, a brain tumor cell, a breast cancer cell, an MCF7 cell, a HeLa cell, a CTC (Circulating Tumor Cell), or a CTSC (Circulating Tumor Stem Cell). ### Claim 10 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the conducting polymer is polyacetylene, polypyrrole, polythiophene, poly-PEDOT (poly(3,4-ethylenedioxythiophene)), polyaniline, or a derivative thereof. ### Claim 11 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the composition has a nanowire structure, a nanohair structure, or a nanopillar structure. ### Claim 12 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the composition is attached onto a surface of gold (Au), platinum (Pt), silver (Ag), copper (Cu), iron (Fe), or ITO (Indium Tin Oxide). ### Claim 13 (depends on 1) The method for detecting a pathogenic material of claim 1, wherein the detecting is measuring a change in an electric current. ### Claim 14 A disease diagnostic apparatus comprising a doped composition, wherein the doped composition is comprised of a dopant and a conducting polymer. ### Claim 15 (depends on 14) The disease diagnositic apparatus of claim 14, wherein the dopant is doped into the conducting polymer. ### Claim 16 (depends on 14) The disease diagnostic apparatus of claim 14, wherein the disease diagnostic apparatus is a biosensor. ### Claim 17 A method for acquiring a pathogenic material, comprising contacting a sample comprising the pathogenic material with a doped composition comprising a dopant and a conducting polymer. ### Claim 18 (depends on 17) The method for acquiring a pathogenic material of claim 17, comprising changing voltage, changing current, or adding a compound. ### Claim 19 (depends on 18) The method for acquiring a pathogenic material of claim 18, wherein the compound is glutathione.