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US 2015/0141378 A1Published application
Nitroxyl progenitor compounds and methods of use
AssigneeThe Johns Hopkins University
InventorsJohn P. Toscano, Christopher M. Pavlos, Preeya Kapur Boppana
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Abstract
Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.
Claims25
-52. (canceled)
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is alkyl, perhaloalkyl, or aryl, the alkyl and aryl are optionally substituted with from 1-4 groups selected from the group consisting of halo, CN and COOH;
- R2 is aryl optionally substituted with from 1-4 groups selected from the group consisting of halo, NO2, CN, CF3 and COOH;
- or R1 and R2, together with the nitrogen to which they are both attached, form a heterocycloalkyl, heterocyclyl or heteroaryl ring, wherein the heterocycloalkyl, heterocyclyl or heteroaryl ring is optionally substituted with from 1-4 groups selected from the group consisting of halo, COOH, NO2 and ═O;
- m is 0;
- and
- n is 0.
4 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.