Cochleates made with soy phosphatidylserine
AssigneesRutgers, The State University of New Jersey, Coordinated Program Development, LLC
InventorsRAPHAEL MANNINO, RUYING LU
Life of this patent
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Abstract
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
Claims41
A cochleate, comprising:
- a soy-based phospholipid comprising about 40%-74% by weight soy phosphatidylserine,
- a multivalent cation, and
- a bioactive drug.
A method for administering a cochleate to a subject, the method comprising:
- administering the cochleate to the subject, wherein the cochleate comprises (i) a soy-based phospholipid that comprises about 40%-74% by weight soy phosphatidylserine, (ii) a multivalent cation, and (iii) a bioactive drug, wherein the cochleate is prepared by a process comprising the steps of:
- (a) mixing a solution of the bioactive drug and the soy-based phospholipid to form a suspension of liposomes in an aqueous medium, wherein the liposomes comprise (i) a lipid bilayer comprising soy phosphatidylserine in an amount of about 40%-74% by weight of the lipid bilayer and (ii) the bioactive drug;
- (b) adding a multivalent cation to the suspension of liposomes of (a) to form the cochleate;
- and
- (c) collecting the cochleate.
29-35. (canceled)
A method of administering a cochleate to a subject, the method comprising administering the cochleate to the subject, wherein the cochleate comprises (i) a soy-based phospholipid that comprises about 40%-74% by weight soy phosphatidylserine, (ii) a multivalent cation and (iii) a bioactive drug.
Dependencies are inferred from the claim text.