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US 2015/0133302 A1Published application
Degradable thiol-ene polymers
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsChristopher BOWMAN, Kristi ANSETH, Bilge HACIOGLU, Charlie NUTTELMAN
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Abstract
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
Claims31
1-15. (canceled)
A composition comprising:
- (a) a photopolymerized biocompatible cross-linked degradable thiol-ene hydrogel polymer comprising a thiol component and an ene component;
- and
- (b) a cell, tissue, tissue aggregate, protein, pharmacologically active agent, or agricultural chemical.
A method for producing a polymeric material comprising (a) a biocompatible cross-linked degradable thiol-ene hydrogel polymer;
- and (b) a cell, tissue, tissue aggregate, protein, pharmacologically active agent, or agricultural chemical, the method comprising:
- subjecting a polymerization reaction mixture comprising a thiol compound and an olefin compound to a radical polymerization reaction under conditions sufficient to produce a biocompatible cross-linked degradable thiol-ene hydrogel polymer, wherein the thiol compound comprises m number of reactive thiol groups, and the olefin compound comprises n number of reactive ene groups, and wherein each of n and m is an integer of at least 2, provided the sum of n+m is at least 5;
- and wherein (i) the polymerization reaction mixture further comprises a cell, tissue, tissue aggregate, protein, pharmacologically active agent, or agricultural chemical for encapsulation within the polymer, or (ii) the method further comprising derivatizing the thiol compound, the ene compound or the polymer with a protein, pharmacologically active agent, or agricultural chemical.
Dependencies are inferred from the claim text.