Compositions and kits for diagnosing infections

A composition adapted for pulmonary administration to a patient to be diagnosed for the existence or absence of a bacterial lung infection, said composition consisting essentially of a diagnostic effective amount of isotopically labeled citrulline or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable excipient, a propellant and optionally, a solvent and a dispersant, said composition being further adapted for single use.

A composition adapted for oral administration to a patient to be diagnosed for the existence or absence of a bacterial lung infection, said composition consisting essentially of a diagnostic effective amount of isotopically labeled citrulline or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, additive, or excipient.

A unit dosage form kit comprising a single use container and a diagnostically effective amount of isotopically labeled citrulline, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, additive, or excipient.

A kit comprising at least one unit dosage of isotopically labeled citrulline or a pharmaceutically acceptable salt thereof, and at least one device for the delivery of the isotopically labeled citrulline to a patient or at least one breath collection device, or a combination of such devices.

Isotopically labeled citrulline, or a pharmaceutically acceptable salt thereof, comprising 13C, 14C, 17O, 18O, 15N, or mixture thereof, wherein the 13C, 14C, 17O, 18O, or 15N is present in an amount greater than natural abundance.