Methods of using isoniazid for the diagnosis of lung infections
AssigneesStc.Unm, The Johns Hopkins University
InventorsGraham Timmins, Seong Choi, Zachary Sharp, Viorel Atudorei, Mamoudou Maiga, William Bishai
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Abstract
The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid.
Claims14
A method for determining the presence or absence of a bacterial infection in the lungs of a patient comprising:
- administering to the lungs of the patient a diagnostically effective amount of 15N-labeled isoniazid and optionally, isotopically labeled urea;
- collecting one or more samples of exhaled breath from the subject;
- and
- determining the amount of 15N-labeled nitrogen gas in said samples;
- said amount indicating the presence or absence of the bacterial infection in the lungs of the patient.
A single use composition consisting essentially of a diagnostically effective amount of a compound of the following formula
- optionally, isotopically labeled urea;
- and
- a pharmaceutically acceptable excipient, propellant, solvent, dispersant, diluent, or combination thereof.
A kit comprising at least one single use composition comprising a diagnostically effective amount of 15N-labeled isoniazid, at least one breath collection device, and instructions for using the kit to diagnose the presence or absence of a bacterial infection in the lungs of a patient.
Dependencies are inferred from the claim text.