Implantable silk-based tissue prostheses
AssigneeAllergan, Inc.
InventorsDavid Kaplan, Gregory H. Altman, Rebecca Horan, David Horan
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Abstract
A silk fiber based matrix composition comprising spider silk that can be biodegradable, from the spider species Nephila clavipes (or from genetically engineered bacteria making Nephila clavipes silk), and in the form of a mesh or film.
Claims20
A tissue prosthesis comprising a matrix of sericin-extracted silkworm fibroin fibers, said fibers being biocompatible and helically organized into fiber bundles, wherein said matrix supports ingrowth of cells around said fibroin fibers and is biodegradable.
The prosthesis as recited in claim 13, wherein the matrix is in the form of a mesh.
A smooth muscle prosthesis comprising a matrix of sericin-extracted silkworm fibroin fibers, said fibers being biocompatible and helically organized into fiber bundles.
An implantable, silk-fiber-based mesh comprising helically organized fiber bundles of sericin-extracted biodegradable silkworm fibroin fibers.
Dependencies are inferred from the claim text.