Process for preparing n-(5-chloro-2-isopropylbenzyl)cyclopropanamine
AssigneeBayer CropScience AG
InventorsThomas Himmler, Sandra Lehmann, Thomas Norbert Muller, Mathias Riedrich, Lars Rodefeld, Frank Volz, Sascha Von Morgenstern
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Abstract
The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.
Claims13
N-(5-Chloro-2-isopropylbenzyl)cyclopropanamine of the formula (I)
A process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine of the formula (I)
- characterized in that
- (d) N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine of the formula (III)
- is hydrogenated over specific platinum catalysts.
2-Bromo-4-chloro-1-isopropylbenzene of the formula (IV)
A process for preparing 2-bromo-4-chloro-1-isopropylbenzene of the formula (IV)
- characterized in that
- i) a diazonium salt of the formula (IX)
- where X is HSO4, Cl, Br, HCO2, CH3CO2 or H2PO4
- is reacted with CuCl, FeCl2 or FeSO4 and aqueous HCl or metal chloride.
The use of a compound selected among the list consisting of compound II to XI to prepare N-(5-Chloro-2-isopropylbenzyl)cyclopropanamine of the formula (I)
Dependencies are inferred from the claim text.